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Ozempic Vs Mounjaro: Semaglutide Vs. Tirzepatide

Ozempic Vs Mounjaro

ozempic vs mounjaro semaglutide vs tirzepatide

Ozempic Vs Mounjaro is a comparison of two weekly diabetes medicines, Semalgutide and Tirzepatide.

Both these drugs are compared and presented here in table format for easy understanding.

Ozempic Vs Mounjaro: Basics

Ozempic

Mounjaro

Class GLP-1 analog Dual GLP-1 and GIP analog
Drug Semaglutide Tirzepatide
Manufacturer Novo Nordisk Eli Lilly
Uses (Approved Indication) Diabetes Type 2 Diabetes Type 2

Both Ozempic and Mounjaro have got approval from the FDA for the treatment of Diabetes Type 2. Semaglutide has also been approved for oral use by the brand name Rybelsus.

Rybelsus is also approved only for the treatment of Type 2 Diabetes. It is taken as a once-daily oral tablet alone or in combination with Jardiance, Farxiga, Metformin, Insulin, or sulfonylurea.

Wegovy is a once-weekly high-dose Semaglutide that has been approved only for the treatment of obesity and weight loss.

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Ozempic Vs Mounjaro: Dosing

Dosage and Formulations

Ozempic

Mounjaro

Formulation 0.5 ml pen injector that contains:

  • 0.25 mg/ 0.5 ml
  • 0.5 mg/0.5 ml
  • 1 mg/0.5 ml
0.5 ml pen injector that contains:

  • 2.5 mg/ 0.5 ml
  • 5 mg/0.5 ml
  • 7.5 mg/0.5 ml
  • 10 mg/0.5 ml
  • 12.5 mg/0.5 ml
  • 15 mg/0.5 ml
Dose 0.25 mg once weekly for 4 weeks, then 0.5 mg once weekly for 4 weeks or continued.

After 4 weeks, the dose may be increased to 1 mg per week for 4 weeks up to 2 mg per week

2.5 mg once weekly for 4 weeks, then 5 mg once weekly for 4 weeks or continued.

After 4 weeks, the dose may be increased at monthly intervals to 7.5 mg, 10 mg, 12.5 mg, and then 15 mg per week maximum

How to administer Subcutaneous in the skin Subcutaneous in the skin

Both Ozempic and Mounjaro are administered once weekly into the skin. Both these drugs are given in a low dose for four weeks after which the dose is increased.

The maximum dose of Ozempic, as per the manufacturer’s labeling is 1 mg weekly. However, recently the maximum dose has been increased to 2 mg once weekly for the treatment of Diabetes Mellitus.

Mounjaro (Tirzepatide) is administered as a 2.5 mg injection weekly for four weeks. The dose is then increased to 5 mg which is the usual starting anti-diabetic dose.

The maximum recommended dose of Mounjaro is 15 mg once a week.

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Ozempic Vs Mounjaro: A1C and Weight Loss

Efficacy

Ozempic

Mounjaro

A1C reduction
  • 0.5 mg: 1.5%
  • 1 mg: 1.86%
  • 5 mg: 2.01%
  • 10 mg: 2.24%
  • 15 mg: 2.30%
Weight Loss
  • 0.5 mg: 4.6 kg
  • 1 mg: 5.7 kgs – 6.5 kgs
  • 5 mg: 7.6 kgs
  • 10 mg: 9.3 kgs
  • 15 mg: 11.2 kgs

Ozempic vs Mounjaro for Diabetes: Effect on A1C:

Both Ozempic and Mounjaro are two highly potent diabetes medications. These drugs have shown superior efficacies in the management of diabetes compared to all the currently available diabetes medications.

When comparing Ozempic with Mounjaro, both 0.5 mg and 1 mg Ozempic have comparable A1C-lowering effects vs low-dose Mounjaro in a dose of 5 mg once weekly.

Mounjaro in a dose of 10 mg and 15 mg weekly, however, demonstrated superiority over Ozempic 0.5 mg and 1 mg administered once a week.

Mean difference in A1C between Ozempic and Mounjaro

Ozempic dose

Mounjaro dose

Which is better

0.51% 0.5 mg 5 mg Mounjaro
0.15% 1 mg 5 mg Comparable
0.74% 0.5 mg 10 mg Mounjaro
0.38% 1 mg 10 mg Mounjaro
0.8% 0.5 mg 15 mg Mounjaro
0.44% 1 mg 15 mg Mounjaro
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Ozempic Vs Mounjaro for Diabetes: Effect on Body Weight:

Among the six weight loss medicines that have been approved, Semaglutide has shown superior results. However, the low-dose formulation, Ozempic is not approved for weight loss.

Likewise, the FDA approval of Mounjaro as a weight loss (anti-obesity) medicine is still pending.

Since both Ozempic and Mounjaro are associated with significant weight loss, we compared the weight loss effects of both these drugs.

Ozempic in a dose of 0.5 mg is associated with about 4.6 kg of weight loss while 1 mg is associated with 5.7 to 6.5 kg of weight loss.

On the other hand, the weight loss effect of 15 mg Mounjaro is double that of Ozempic 1 mg. High dose Semaglutide, Wegovy has been associated with a maximum weight loss of 16% while Mounjaro is associated with 22% body weight loss.

Drug

Dose

Weight Loss

Ozempic 0.5 mg 4.6 kg
1 mg 5.7 – 6.5 kg
Mounjaro 5 mg 7.6 kg
10 mg 9.3 kg
15 mg 11.2 kg

Mounjaro is associated with greater weight loss even in low doses compared to high-dose Ozempic.

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Ozempic Vs Mounjaro Side effects

Side effects

Ozempic

Mounjaro

Contraindications Allergic reactions

MEN II syndrome

Medullary thyroid carcinoma

Allergic reactions

MEN II syndrome

Medullary thyroid carcinoma

Pancreatitis 13 out of 14 cases
Diabetic Retinopathy With background disease: 3% vs 1.8 % in the placebo

Without background disease: 8.2% vs 5.2% in the placebo

Hypoglycemia
  • 0.5 mg: 16.7%
  • 1 mg: 29.8%

vs 15.2% in the placebo

  • 5 mg: 16%
  • 10 mg: 19%
  • 15 mg: 14%

Vs 13% in the placebo

Acute renal failure Can cause acute renal failure Can cause acute renal failure
Nausea
  • 0.5 mg: 15.8%
  • 1 mg: 20.3%
  • 5 mg: 12%
  • 10 mg: 15%
  • 15 mg: 18%
Vomiting
  • 0.5 mg: 5%
  • 1 mg: 9.2%
  • 5 mg: 5
  • 10 mg: 5
  • 15 mg: 9
Diarrhea
  • 0.5 mg: 8.5%
  • 1 mg: 8.8%
  • 5 mg: 12
  • 10 mg: 13
  • 15 mg: 17
Abdominal pain
  • 0.5 mg: 7.3%
  • 1 mg: 5.7%
  • 5 mg: 6%
  • 10 mg: 6%
  • 15 mg: 5%
Constipation
  • 0.5 mg: 5%
  • 1 mg: 3.1%
  • 5 mg: 6%
  • 10 mg: 6%
  • 15 mg: 7%
Gallstones
  • 0.5 mg: 1.5%
  • 1 mg: 0.4%
0.6%
Amylase 13% 38%
Lipase 22% 42%
Injection site reaction 0.2% 3.2%
Fatigue 0.4%
Heart rate 2 – 3 beats per minute 2 – 4 beats per minute

The side effects of both Ozempic and Mounjaro are comparable. Since both these drugs have a similar mechanism of action and both are incretins, both these drugs can cause pancreatitis.

The incidence of medullary thyroid cancer is not well known but both these drugs should not be given to individuals who have a history of medullary thyroid cancer or MEN-II syndrome.

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Ozempic Vs Mounjaro Drug Interactions

Drug Interactions

Ozempic

Mounjaro

Avoid
  • Bexarotene
  • Gatifloxacin
  • Bexarotene
  • Gatifloxacin
Monitor when given in combination with Ozempic or Mounjaro
  • Levothyroxine
  • Warfarin
  • Metformin
  • Digoxin
  • Atorvastatin
  • Ethinylestradiol, and
  • Levonorgestrel
  • Clarithromycin
  • Clozapine
  • Protease inhibitors
  • Diuretics
  • Salmeterol
  • Insulin
  • Oral Contraceptives
  • Oral antidiabetic medications
  • Warfarin
  • Corticosteroids
  • Diuretics
  • Fenofibrate
  • Salmeterol
  • Antidepressants (MAO inhibitors)

In summary:

Ozempic and Mounjaro are highly potent drugs used in the treatment of diabetes mellitus. They have significant weight loss effects and lower the A1C significantly.

Mounjaro has superior A1C-lowering effects and is associated with greater weight loss compared to Ozempic.

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What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese and have diabetes, hypertension, and high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.
Also, you can contact me directly at dibesity.com@gmail.com

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