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Semaglutide (Rybelsus, Ozempic, and Wegovy) for Diabesity

Semaglutide for Diabesity

semaglutode rybelsus ozempic and wegovy

Semaglutide is a newly approved GLP-1 analog. It has been approved for the treatment of diabetes and obesity.

It is one of the five weight-loss drugs that has been approved by the FDA for the treatment of obesity.

The other four weight-loss drugs that have been previously approved are:

  • Orlistat (Xenical)
  • Liraglutide (Saxenda and Victoza)
  • Phentermine/ Topiramate ER (Qsymia)
  • Naltrexone ER/ Bupropion ER (Contrave)

Lorcaserin (Belviq) was previously approved for weight loss but has been withdrawn from the markets because of its association with cancers.

Liraglutide and Semaglutide are the two GLP-1 analogs that have been approved for the treatment of diabesity (diabetes and obesity).

So, which weight loss drug induces more weight loss?

semaglutode rybelsus ozempic and wegovy

Wegovy Comparison with Other Weight Loss Drugs

Semaglutide (Rybelsus, Ozempic, and Wegovy) MOA (Mode of action):

Semaglutide is a novel GLP-1 analog that has 94% similarity in structure to the endogenous GLP-1. It reduces blood glucose in a glucose-dependent manner.

Hence, it does not cause hypoglycemia unless it is used in combination with either insulin or sulfonylureas.

It also acts on the central receptors in the hypothalamus that modulates satiety. It binds to the hunger and satiety receptors in the brain. This results in a dual action:

  • Less craving for foods with the high glycemic index
  • Suppression of hunger.

Semaglutide also inhibits stomach motility and causes gastric fullness. Inhibition of gastric motility causes stomach distension and induces nausea. In fact, nausea is the most common side effect of GLP-1 analogs.

What is Rybelsus? Side effects, Drug Interactions, & Concerns

What is the difference between Rybelsus, Ozempic, and Wegovy?

Rybelsus is a tablet formulation of Semaglutide. It is available in a dose of 3 mg, 7 mg, and 14 mg oral tablets that are taken by the patients once daily after meals.

It is primarily indicated for the treatment of diabetes. Rybelsus treatment is initiated in a dose of 3 mg.

What is Wegovy, Rybelsus, and Ozempic? Efficacy in DM and Obesity

Ozempic is an injectable formulation of Semaglutide that is administered once a week. It is administered in a dose of 0.25 mg and 0.5 mg as once a week subcutaneous injection.

The dose is given once weekly subcutaneously starting from the lowest dose of 0.25 mg which is then titrated upwards if required.

Wegovy is a high-dose injectable Semaglutide administered in a dose of 2.4 mg once weekly under the skin. It is primarily indicated for the treatment of obesity.

Ozempic Weight Loss Reviews by Real Patients @ Reddit

How effective is Semaglutide in lowering the Glycated hemoglobin (A1C)?

Different formulations of the drug have been shown to have variable efficacy in the treatment of diabetes mellitus.

Furthermore, the baseline Glycated hemoglobin, intensive lifestyle intervention, and concomitant medications may also influence the decline in glycated hemoglobin.

Rybelsus efficacy in the treatment of Diabetes:

  • Oral Rybelsus has been evaluated in a 52-weeks clinical trial. In a dose-escalated manner, it resulted in a decline in glycated hemoglobin of 1.2% from the baseline.

Ozempic efficacy in T2DM patients:

  • Ozempic administered in a dose of 0.5 mg once weekly resulted in lowering glycated hemoglobin by 1.2%. When administered in a dose of 1 mg subcutaneously weekly, it resulted in a reduction of glycated hemoglobin by 1.8%.

Wegovy (High dose Injectable Semaglutide) in T2DM:

  • Wegovy is a high-dose injectable Semaglutide. It causes a reduction in glycated hemoglobin by 1.8% to 2.4%.
semaglutide rybelsus vs ozempic vs Wegovy effect on HbA1C

semaglutide rybelsus vs ozempic vs Wegovy effect on HbA1C

How much weight loss is expected with the use of Semaglutide?

Semaglutide is considered a promising weight-loss drug. Wegovy, a high dose once-weekly injectable Semaglutide, has been FDA-approved for the treatment of obesity.

It causes weight loss via multiple mechanisms including early satiety, postprandial fullness, and central mechanisms.

Rybelsus administered orally has been shown to cause a mean weight loss of about 4.4 kgs over six months to one year.

Rybelsus for Weight Loss in Non Diabetic Patients

Ozempic is a low dose once-weekly Injectable Semaglutide that causes a weight loss of about 13 pounds (6 kgs) over 6 months to one year.

semaglutide rybelsus vs ozempic
Rybelsus vs Ozempic: Comparing weight loss effects of the two drugs

Wegovy is a high-dose once weekly Injectable Semaglutide that causes a weight loss of about 16% from the baseline.

The STEPS Trials showed the superiority of Wegovy over placebo. It also suggested that weight loss is maintained over a long period of time even after treatment discontinuation.

Before and After Pictures & Reviews of People who are using Ozempic

In Conclusion;

Semaglutide causes a significant reduction in glycated hemoglobin and weight in obese patients with diabetes.

It may replace Liraglutide in the treatment of patients with Diabesity.

Review Rybelsus: Rate your experience here

What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese, have diabetes, hypertension, high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.

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