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Rybelsus Reviews & Ratings (Weight loss effects and Efficacy in Diabetes)

Rybelsus reviews by real patients are considered one of the main factors in choosing an antidiabetic medicine. Reviews by real patients in real-life situations are considered more realistic than data presented in clinical trials.

Rybelsus is an oral GLP-1 analog, generic being Semaglutide. It is available in 3 mg, 7 mg, and 14 mg tablets.

Treatment is initiated in a dose of 3 mg which is then increased at weekly intervals to 7 and 14 mg if required. Other formulations of Semaglutide are Ozempic and Wegovy.

Wegovy is FDA approved for weight loss

You can rate your experience using Rybelsus and write a review or mail us your review at We will publish your reviews here at the end of this post.

Some of the Rybelsus reviews are posted here. These are taken from various sources on the internet.

Rating on various sites for Rybelsus varies between 6 and 10 on a score of 1 to 10. 1 score being the worst experience and 10 being the best.

Rybelsus & Ozempic for Weight Loss and Side effects Reviews

Overall, about 60% of patients rate a positive experience, and 30% rate is negative.

Rybelsus Reviews from WebMd:

A total of three reviews were found as of today. The results are shown in the picture below:

% Rybelsus Reviews & Ratings (Weight loss effects and Efficacy in Diabetes)
Rybelsus reviews at WebMD. An overall score of 2.8 out of 5 was given by users [Ref].
Among the three users who rated oral Rybelsus, one had a positive review. The other two developed serious side effects including nausea, vomiting, didn’t feel like eating, and low blood glucose.

Semaglutide Side Effects (Rybelsus, Ozempic, and Wegovy)

One patient reported palpitations and had a heart rate of 130 per minute (from a baseline of 100 per minute).

The same patient also stated that he had very bad dreams and wished to have eaten the whole refrigerator.

Rybelsus Reviews at

A total of 80 reviews have been posted at Here is a screenshot:

rybelsus reviews by drugs
Patients rated Rybelsus 6.5 out of 10 at

Some patients rated it awesome. One patient reported a drop in HbA1C from 9.7 to 5.1 and lost about 50 lbs.

One pre-diabetic patient with a BMI of more than 30 kg/m² rated it 10 out of 10, hoping to lose weight as he did not achieve weight loss targets with regular exercise and 16 hours of fasting daily.

He did not experience any drug-related side effects with 3 mg and planned to increase the dose to 7 mg.

Another pre-diabetic patient lost 30 lbs after four months without exercise. He only reported nausea but that was not troublesome.

What is Wegovy, Rybelsus, and Ozempic? Efficacy in DM and Obesity

Another patient who had uncontrolled diabetes achieved excellent glycemic control and lost 24 lbs in just six weeks.

One obese diabetic patient achieved excellent glycemic control and lost significant weight from 335 lbs to 285 lbs in six months (50 lbs).

Most patients who gave less rating to the drug were because of the stomach-related side effects of the drug. One patient gave it three stars because of severe nausea, indigestion, vomiting, and rapid heart rate.

What is Rybelsus? Side effects, Drug Interactions, & Concerns

Rybelsus reviews at Reddit:

Most users here had similar experiences. People had the same gastrointestinal side effects with nausea being dominant. Most users had suppressed appetite.

One patient reported that he experienced food restriction similar to what he had for the first six months after sleeve gastrectomy. Now that he was 10 years post-bariatric surgery, he wanted to stop weight regain and Rybelsus was the answer.

Wegovy vs Sleeve Gastrectomy: Weight Loss Medicine Vs Surgery

Constipation was another side effect people talked about here. One patient got relieved of constipation with simple magnesium OTC medicines.

One patient mentioned USD 900 as the price of 30 pills. Since his insurance did not cover that, he was upset.

Other patients in Denmark get the same pills for USD 130 (compared to USD 3 for metformin). Some patients were so optimistic that they were paying from their own pockets.

Rybelsus for the treatment of Diabesity

Sleep disorder as a side effect of Rybelsus:

When searching for Rybelsus reviews, I noticed this strange side effect reported by quite a number of patients. Patients had palpitations and insomnia.

There is little explanation for sleep problems at this time, however, because it affects the central hunger pathways, it may also have some effect on the reticular activating system. This could be one explanation.

Another could be simply abdominal bloating, nausea, heartburn, vomiting, and abdominal pain that does not let a person sleep.

Ozempic Weight Loss Reviews by Real Patients @ Reddit

One patient reported a severe abdominal muscle spasm that he developed a hernia.

Apart from the gastrointestinal side effects, no major life-threatening adverse drug reactions were reported in all the clinical reviews.

Rybelsus Reviews and Ratings at

Rybelsus is not an FDA-approved drug for weight loss. The only FDA-approved formulation of Semaglutide is Wegovy which is a high dose once-weekly injectable Semaglutide.

However, the weight loss effects of Rybelsus have been comparable to Liraglutide. It is of note that Liraglutide has been approved by the FDA for weight loss. Furthermore, Liraglutide is an injectable medicine while Rybelsus is taken orally once daily.

To help other patients choose the best diabetes medicine, please answer a few of the questions mentioned here.

Rybelsus for Weight Loss in Non Diabetic Patients

Summary of Rybelsus Reviews at

Until now, 83% of the patients have rated a positive response using Rybelsus and achieved more weight loss than they expected while 17% achieved weight loss as expected.
With Ozempic, one patient had a bad experience, did not lose weight, and had more side effects while one patient had a neutral effect.
On Reddit, people who have been using Ozempic observed weight loss soon after treatment initiation.
The most common side effect documented with Rybelsus is constipation. One patient has been using Weovy and reported an excellent response with Wegovy.
  • Question of

    How do you rate your weight loss experience with Wegovy?

    • 😰😰 Terrible (Instead Gained Weight)
    • 👎👎 Bad experience (Little weight loss, more side effects)
    • 😐😐 Neutral (Some weight loss)
    • 😊😊 Good (Weight loss as expected)
    • 😍😍👌👌 Excellent (More weight loss than expected)
  • Question of

    How do you rate your weight loss experience with Rybelsus?

    • 😰😰 Terrible (Instead Gained Weight)
    • 👎👎 Bad experience (Little weight loss, more side effects)
    • 😐😐 Neutral (Some weight loss)
    • 😊😊 Good (Weight loss as expected)
    • 😍😍👌👌 Excellent (More weight loss than expected)
  • Question of

    How do you rate your weight loss experience with Ozempic?

    • 😰😰 Terrible (Instead Gained Weight)
    • 👎👎 Bad experience (Little weight loss, more side effects)
    • 😐😐 Neutral (Some weight loss)
    • 😊😊 Good (Weight loss as expected)
  • Question of

    Do you recommend Rybelsus for weight loss?

    • Never
    • No
    • May be
    • Yes
    • Definitely
  • Question of

    If you have tried weight loss medicines previously, which one do you think is the most effective?

    • I have not tried any weight loss medicines in the past
    • Orlistat (Xenical)
    • Phentermine/ topiramate (Qsymia)
    • Naltrexone/ Bupropion (Contrave)
    • Liraglutide (Saxenda, Victoza)
    • Lorcaserin (Belviq)
    • Rybelsus (Semaglutide)
  • Question of

    What was the most common side effect you had when using Rybelsus?

    • Nausea
    • Constipation
    • Abdominal pain
    • Sleep disorders
    • hypoglycemia

What do you think?

Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

Here is a link to My Facebook Page. You can also contact me by email at or at My Twitter Account
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