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Rybelsus Vs Wegovy: A Comparison of Weight Loss Effects

Rybelsus Vs Wegovy

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Rybelsus vs Wegovy? Both drugs belong to the same class of medicines but which drug is the most effective for the treatment of obesity?

Until now, Semaglutide is only marketed by Novo Nordisk. It is marketed as three different formulations:

  • Rybelsus,
  • Ozempic, and
  • Wegovy

Rybelsus and Ozempic are FDA-approved for the treatment of Diabetes, while Wegovy is FDA-approved only for the treatment of obesity.

Wegovy Comparison with Other Weight Loss Drugs

Different Semaglutide Formulations:

Rybelsus is available as oral tablets formulation in doses of:

  • 3 mg,
  • 7 mg, and
  • 14 mg.

Ozempic and Wegovy are injectable formulations of Semaglutide that are administered via subcutaneous injections once weekly.

Rybelsus Weight Loss Before and After & Pictures & Reviews

Ozempic is given in doses of:

  • 0.25 mg per week for four weeks, followed by 0.5 mg per week for four weeks.
  • Patients who are well controlled on 0.5 mg are advised to continue 0.5 mg, while those patients who do not achieve their glucose targets are advised to increase the dose to the maximum of 1 mg subcutaneous weekly.

Before and After Pictures & Reviews of People who are using Ozempic

Wegovy is advised for obese patients in the following doses:

  • 0.25 mg per week for four weeks
  • 0.5 mg per week for four weeks
  • 1 mg per week for four weeks
  • 1.7 mg per week for four weeks, and then the maintenance dose of
  • 2.4 mg per week.

The maintenance and the maximum dose of Wegovy is 2.4 mg per week.

Wegovy Weight Loss Before and After Pictures with Reviews

Rybelsus vs Wegovy: Which formulation of Semaglutide is associated with the greatest weight loss?

Although Rybelsus is not a weight-loss drug. It has only been approved by the FDA for the treatment of Diabetes, it has been observed to cause significant weight loss.

On the other hand, Wegovy, an injectable formulation of Semaglutide is primarily approved as a weight-loss drug.

It is thus logical to presume that Wegovy, a weight-loss drug, must be superior to Rybelsus, a non-weight loss drug.

However, we should look into the evidence too. The two formulations have not been compared for weight loss in a head-to-head clinical trial, we are comparing the weight loss effects of these drugs in clinical trials compared to placebo medicine.

Wegovy vs Sleeve Gastrectomy: Weight Loss Medicine Vs Surgery

Weight loss with Rybelsus:

Rybelsus is the same drug as Wegovy. The formulations and the doses differ.

Rybelsus is associated with significant weight loss compared to placebo. This is shown in the table below:

Baseline Weight Weight after 26 weeks Mean Weight Loss
Placebo 88.6 87.2 -1.4 kgs
Rybelsus 7 mg 89 86.7 -2.3 kgs
Rybelsus 14 mg 88.1 84.4 -3.7 kgs
rybelsus weight loss in diabetics after 26 weeks
The weight loss effects of Rybelsus 7 mg and 14 mg vs placebo medicine

Rybelsus has superior efficacy when compared with metformin, Januvia, and Jardiance. Compared to Liraglutide, it has comparable weight loss effects.

Rybelsus for Weight Loss in Non Diabetic Patients

Weight loss with Wegovy:

Wegovy got FDA approval for weight loss after the STEPs Trials. Results of the STEPs trials have been discussed in detail here: What is Wegovy, Rybelsus, and Ozempic? Efficacy in DM and Obesity

The weight loss effects in these clinical trials ranged from 9.6% to 16%. Furthermore, it was also effective in the maintenance treatment of obesity compared to placebo.

wegovy weight loss summary

Wegovy weight loss summary in the four STEPS clinical trials

Compared to Ozempic and Rybelsus, Wegovy is associated with greater weight loss as shown below:

wegovy vs rybelsus vs ozempic weight loss effects
Wegovy weight loss effect compared with Rybelsus and Ozempic

Rybelsus is associated with a mean weight loss of about 8 pounds or 4.4% of the body weight. Wegovy, on the other hand, is associated with about 16% weight loss.

In conclusion:

Although Rybelsus is an easy to take oral medicine and is associated with significant weight loss, it is still much less effective compared to Wegovy in terms of its weight loss effects.

What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese, have diabetes, hypertension, high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.

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