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Semaglutide Vs Orlistat (Wegovy, Ozempic, and Rybelsus Vs Xenical)

Wegovy vs Orlistat

wegovy vs orlistat xenical

Semaglutide Vs Orlistat compares the two drugs. Semaglutide is a novel GLP-1 analog indicated for the treatment of diabetes and obesity. Orlistat is only indicated for the treatment of obesity.

Semaglutide, a GLP-1 analog that acts as endogenous incretin. Incretins are hormones that come from the acronym “INTestinal SeCRETion of IN“Sulin”.

Incretins are hormones released when there is a glucose load. GLP-1 (Glucagon-like peptide, and Gastric inhibitory peptide) is the most common endogenous incretins.

Wegovy is a GLP-1 analog. It is the brand name of Semaglutide injection administered once a week. Recent clinical trials have shown the superiority of Wegovy over most of the FDA-approved weight-loss drugs including Orlistat (Xenical).

Wegovy Comparison with Other Weight Loss Drugs

Most drugs used for weight loss in the past are not used nowadays. Physicians are not comfortable risking their patients’ health for a weight loss of just a few pounds.

Lorcaserin (Belviq) has already been removed from the market because of the drug’s cancer-causing potential.

The maximum weight loss observed with all the weight loss medicines does not exceed 10%. Wegovy on the other hand has been observed to cause a weight loss of up to 16%.

Before and After Pictures & Reviews of People who are using Ozempic

Furthermore, the weight loss effect of the drug is maintained when Wegovy is continued beyond one to two years.

Wegovy causes a weight loss of up to 16% from the baseline

Semaglutide: Rybelsus, Ozempic, and Wegovy

Semaglutide is a drug that is primarily used to control blood glucose. Based on the findings, Semaglutide seems to hold a lot of promise.

This is because, in addition to its favorable side effect profile, it is also more effective than other weight-loss drugs. It provides you with more sustained weight loss.

Semaglutide (Rybelsus, Ozempic, and Wegovy) for Diabesity

Studies have shown that while most weight loss drugs used in clinical trials offer some short-term results, they tend to be less effective over the long haul.

Second, it reduces hunger. This is why you need to make sure you are able to keep the appetite suppressed while you are using the Semaglutide drug. Third, it has few side effects compared to other oral medications.

What is Rybelsus, Ozempic, and Wegovy?

What is Rybelsus?

Rybelsus, an oral form of Semaglutide, is used to treat diabetes. You can take it orally at a dose of 3, 7, and 14 mg per day. It is often combined with insulin or other anti-diabetic medications and used as an adjunct to exercise and diet.

Clinical trials have shown that oral Semaglutide can reduce glycated hemoglobin by about 1.3%. Dose-dependent, the glucose-lowering effect of oral Semaglutide is also possible.

Rybelsus for Weight Loss in Non Diabetic Patients

In the treatment of Obesity, Rybelsus has been found to cause a weight loss of approximately 8.1 pounds after 26 weeks.

Rybelsus reduces HbA1C by 1.3% and cause a weight loss of 8 pounds

What is Ozempic?

Ozempic, a Semaglutide injectable formulation, is what you will see. It can be administered subcutaneously once a week.

You can get it in either 0.5 mg or 1 mg doses. It can be used as an adjunct to exercise and diet for diabetes treatment.

Ozempic was shown to decrease glycated hemoglobin levels from 1.2% to 1.8%. Ozempic has caused a weight loss of about 13 pounds when administered at doses of 0.5 mg – 1 mg per week.

Ozempic Weight Loss Reviews by Real Patients @ Reddit

What is Wegovy?

It is a high-dose injectable Semaglutide administered once a week in a dose of 2.4 mg. It got recent FDA approval for the treatment of obesity and overweight in patients who have at least one weight-related condition such as diabetes, high cholesterol levels, or hypertension [Ref].

After four large, randomized clinical trials that confirmed its safety and effectiveness, FDA approved Wegovy for weight management and obesity.

Read: The Steps Trials

wegovy vs orlistat weight loss effects semaglutide vs orlistat xenical

Disadvantages of Semaglutide (Rybelsus, Ozempic, and Wegovy)

The first disadvantage of Semaglutide is its price. The tablet formulation, Rybelsus, costs USD 30.90 per tablet. The weekly injection costs more than USD 300 per injection.

Furthermore, most insurance companies might not include Wegovy in their list of medications simply for losing weight.

Although obesity is called the mother of most illnesses, it is not considered to be life-threatening.

Read: Semaglutide Side Effects (Rybelsus, Ozempic, and Wegovy)

The second disadvantage of Semaglutide is its side effects. It has been associated with medullary thyroid cancer and MEN 2 syndrome.

It can cause inflammation of the pancreas, kidney injury, gastrointestinal side effects, and gallbladder disease.

The gastrointestinal side effects affect most individuals and can manifest as bloating, heartburn, excessive abdominal gases, and altered bowel habits.

Rybelsus and Depression: Symptoms Reported on Reddit

Semaglutide has also been associated with worsening symptoms of diabetes-related eye disease (Diabetic retinopathy). lastly, the fear of injection and injection-related side effects are always there.

Conclusion:

Given the long time-course and the long-term usage of glucagon-like peptide-1 (GLP-1), long-term persistence and maintenance of blood glucose levels can be achieved.

This provides a good basis for better metabolic control and improved glycemic control which can possibly lead to a reduction of body weight. GLP-1 analogs have been well tolerated even in high doses of 2.4 mg per week injections (Wegovy).


Orlistat (Xenical):

Orlistat or Xenical is a drug that inhibits the absorption of dietary fats. It is primarily used to treat obese and overweight individuals.

What is Orlistat or Xenical

Orlistat or Xenical is a drug that inhibits the absorption of dietary fats. It is primarily used to treat obese and overweight individuals.

Side effects of Orlistat or Xenical include nausea, vomiting, abdominal cramping, bloating, constipation, sleepiness, and vomiting.

The Pros and Cons of Xenical (Orlistat):

The pros of Xenical are obvious. It is safer than any other fat-loss drug. It has no side effects and has a much lower side-effect profile than those found in other diet pills.

The only downside to Xenical is the fact that it does not work for everyone. It is best for people who consume a lot of fats and oils.

Orlistat (Xenical & Alli) for Weight Loss and Diabetes: Diabesity Reviews

People who consume less dietary fats may not benefit from taking orlistat. Furthermore, most people lose some weight during their initial treatment days but start gaining weight again after some time.

The relapse rate is higher compared to Wegovy, a novel injectable diabetes medicine intended for weight loss in morbidly obese individuals.

Relapse rates are higher with Orlistat compared to Wegovy (semaglutide)

Xenical (Orlistat) should be taken only with food. Xenical is taken with the first bolus of each meal (twice or thrice daily depending on the number of meals per day).

Xenical (Orlistat) causes significant gastrointestinal side effects. It causes the deficiency of fat-soluble vitamins and supplementation with fat-soluble vitamins is usually recommended especially with long-term treatment.

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Recently, the FDA has issued a Black Box warning with Orlistat. More than 30 cases of severe liver injury have been reported.

Patients should be cautious and report any new onset of symptoms such as abdominal pain, nausea, jaundice, or altered sleep pattern after treatment initiation.

Caution: Orlistat causes Liver Injury!

How effective is Xenical (Orlistat)?

It is not a magic pill to lose weight quickly. The short-term weight loss will depend upon the patient’s metabolic response to the drug.

The weight loss with Xenical is variable. It has been estimated to cause a weight loss of 3.05 kg vs. 1.9 kg with a placebo medicine; P <.001 after 6 months of treatment.

Most weight loss physicians are not happy with just 3 kg weight loss. A 120 kgs person losing weight of just 3 kgs is nothing.

Vitamin-Rich, Calorie-Less Best Fruits for Weight Loss

However, when combined with other weight losing therapies and lifestyle modification, the results could be amplified.

Other studies have observed a weight loss of 5 – 10% with orlistat when combined with extensive lifestyle intervention.

Conclusion:

Given the long time-course and the long-term usage of glucagon-like peptide-1 (GLP-1), long-term persistence and maintenance of blood glucose levels can be achieved.

This provides a good basis for better metabolic control and improved glycemic control which can possibly lead to a reduction of body weight. GLP-1 analogs have been well tolerated even in high doses of 2.4 mg per week injections (Wegovy).

Semaglutide Vs Orlistat: Pharmacokinetics

Wegovy (Semaglutide)

Orlistat (Xenical)

Generic Names Semaglutide Orlistat
Indications and Uses Indicated for the treatment of Diabetes Type 2 and Obesity Indicated for weight loss
Formulations
  • Oral Semaglutide: Available by the brand name, Rybelsus
  • Injectable Semaglutide: Available by the brand name, Ozempic, and Wegovy
Available as oral Capsules
Dose
  • Rybelsus is administered orally in a dose of 3 mg, 7mg, or 14 mg daily.
  • Injection Ozempic is administered once weekly in a dose of 0.5 mg and 1.0 mg
  • Injection Wegovy is administered in a dose of 2.4 mg once weekly
Orlistat capsules are given in a dose of 120 mg with meals.

It is usually given with the major meal initially, the dose is then increased to twice and thrice daily if tolerated.

The onset of action One hour 24 to 48 hours
Duration of action 4 to 5 weeks 48 to 72 hours
Half-life elimination One week 1 to 2 hours
The time to Peak Serum Concentration 1 to 3 days 8 hours
Metabolism It is metabolized by proteolytic cleavage It is metabolized within the GIT to inactive metabolites.

Semaglutide Vs Orlistat: Effect on Blood Glucose:

orlistat vs rybelsus vs ozempic hba1c reduction

effect on blood glucose: Semaglutide vs Orlistat

Before and After Pictures & Reviews of People who are using Ozempic

Semaglutide Vs Orlistat: Effect on Bodyweight:

semaglutide vs orlistat weight loss effects
Semaglutide causes significantly more weight loss compared to Orlistat (Xenical)

Read: Wegovy Comparison with Other Weight Loss Drugs

What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese, have diabetes, hypertension, high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.

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