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Mounjaro Questions and Answers: FAQs About Tirzepatide

Mounjaro Questions

Mounjaro Questions and Answers including comparison with Ozempic, Xenical, Contrave, and Interactions with Levothyroxine and Wellbutrin are discussed here.

Here is a list of the commonly asked questions about Mounjaro. These questions are grouped into the following categories:

  • About Mounjaro
  • Mounjaro Dosing
  • Side effects
  • Efficacy in Diabetes
  • Effect on body weight
  • Mounjaro Vs Ozempic and other weight loss drugs
  • Drug Interactions
  • Cost and Insurance

About Mounjaro:

Mounjaro is a Medicine recently approved for the treatment of Diabetes and Obesity. The medical name of Mounjaro is Tirzepatide.

It is a protein with residues similar to GIP (glucose-dependent insulinotropic peptide), GLP-1 (Glucagon-like peptide), and Semaglutide (marketed as Ozempic and Rybelsus).

  • What Class of Drug is Mounjaro?

Mounjaro is a dual GLP-1 and GIP analog. Therefore it is also called “Twincretin” because it mimics the two common incretins present in our body – GLP-1 and GIP. It is the only drug in its class.

  • Which company makes Mounjaro?

Eli Lilly manufactures Mounjaro. The drug is also marketed by Eli Lilly. There are no alternative brands by other manufacturers.

  • What is Mounjaro approved for?

Mounjaro is currently FDA-approved only for the treatment of patients with Diabetes Type 2. It has been recently approved by the FDA for treating obesity under a different brand name, Zepbound.

However, it should not be used to treat Type 1 diabetes and prediabetes.

  • When was Mounjaro approved?

Mounjaro was approved for the treatment of patients with Type 2 diabetes on May, 13th 2022.

On 8th November 2023, the FDA approved Mounjaro to manage obesity.

  • What is Mounjaro Used for?

Mounjaro is used primarily for the treatment of patients with Type 2 diabetes.

It is also indicated for weight loss in diabetics and non-diabetic individuals who are obese or morbidly obese.

  • Is Mounjaro FDA-approved for Weight Loss?

Yes! Tirzepatide has been approved recently by the FDA for weight loss under the brand name, Zepbound.

In clinical trials it was associated with significant weight loss (24% on average) and is used off-label for the management of obesity.

  • When will Mounjaro be approved for weight loss?

Tirzepatide got FDA approval on 8th November 2023 for managing obesity.

  • Is Mounjaro approved for prediabetes, PCOS, or other metabolic conditions?

Mounjaro has not been approved for the treatment of prediabetes, PCOS, metabolic syndrome, or other weight-associated medical conditions.

However, because Mounjaro is associated with significant weight loss, it is likely to get tested in these conditions shortly.

People using Mounjaro for diabetes have noticed a significant improvement in their menstrual cycles, symptoms of PCOS, lipid profile, and other weight-related medical conditions.

  • How does Mounjaro work?

Mounjaro works by acting as GLP-1 and GIP. Both these drugs help regulate blood glucose by stimulating insulin release when the blood glucose levels are high.

In addition, with its GLP-1 activity, it slows stomach motility and makes a person feel full all the time. Hence it is associated with a significant loss of appetite and cravings for food.

Mounjaro also acts on the brain centers and controls food cravings and appetite via central mechanisms.

  • How long does Mounjaro stay in your system?

Mounjaro has a half-life of about 5 days. This means half of the drug is eliminated after 5 days. Generally, when you stop a drug, it takes about 5 half-lives for a drug to be removed from your system.

Hence, for Mounjaro, it will take about 25 to 30 days to stay in your system in amounts of clinical significance and exert some effects.

After 30 days, the levels will drop significantly and may not be detectable (provided you are not injecting it).

  • What drug (medicine) is similar to Mounjaro?

Mounjaro is the only drug classified as a “twincretin” that activates both the incretins in your body. One of these twincretins is GLP-1 and the other is GIP.

Retatrutide is very similar to Mounjaro. It is a triple G agonist. GLP-1, GIP, and Glucagon agonist. Retatrutide and Mounjaro are both drugs by Eli Lilly. 

Retatrutide is similar to Mounjaro except that in addition it also has glucagon-activating properties and is not yet approved for diabetes or weight loss.

Also, Retatrutide is more effective than Mounjaro as it is associated with more significant weight loss, up to 30%.

We don’t have a drug that targets GIP. However, the following drugs are GLP-1 analogs and are somewhat similar to Mounjaro:

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Mounjaro Dosing:

  • What is the usual starting dose of Mounjaro?

Mounjaro is initiated in a dose of 2.5 mg as a subcutaneous injection weekly.

The dose is administered for 4 weeks after which it is increased to 5 mg weekly.

  • For how long do you stay on 2.5 mg Mounjaro?

2.5 mg is the priming dose. It is continued for 4 weeks so that your body gets used to it.

If you are tolerating it without significant side effects, you will have to continue it for four weeks.

  • Can you start Mounjaro at 5 mg?

The manufacturer does not recommend starting Mounjaro directly at a dose of 5 mg weekly injections.

However, if you are using another GLP-1 analog such as Ozempic, and planning to switch to Mounjaro, you may directly switch to Mounjaro to avoid marked fluctuations in your blood glucose.

When switching from Ozempic to Mounjaro, you can switch directly to 5 mg if you are already using Ozempic in a dose of 0.5 mg, 1 mg, or 2 mg per week.

  • Mounjaro 2.5 vs 5 mg: Can you take 2 2.5 mg Mounjaro?

The manufacturer, Eli Lilly, does not recommend combining two smaller doses such as 2.5 mg two injections to make up 5 mg.

However, because of the non-availability of certain dosing during the past few months and of huge demand, people have used such combinations with good efficacy and without added side effects.

  • How long do you stay on Mounjaro 5 mg?

From 5 mg and above, it is considered a treatment dose. If your blood glucose is controlled with the 5 mg weekly injections, you can continue 5 mg beyond four weeks and as long as your diabetes is controlled.

However, if with 5 mg weekly injections of Mounjaro, your blood glucose targets are not achieved, you may increase the dose after 4 weeks to 7.5 mg.

In addition, if you develop side effects with 7.5 mg weekly injections, you can switch back to 5 mg.

  • Can you start Mounjaro at 10 mg?

Starting Mounjaro at 10 mg is not indicated. Even if you want to switch from 1 mg or 2 mg Ozempic to Mounjaro, you should not start at 10 mg.

The starting dose is 2.5 mg but you may start at even 5 mg if you are switching from a higher dose of Ozempic.

10 mg Mounjaro is considered a very high dose and you are likely to develop severe side effects if you start using directly at 10 mg.

However, if you have been using 12.5 mg or 15 mg Mounjaro in the recent past and stopped it or missed a few doses because of some reasons such as non-availability, you may directly start Mounjaro at 10 mg.

  • How long do you stay on mounjaro 10 mg?

You can stay on 10 mg for as long as your diabetes is controlled and you don’t develop side effects.

However, if you develop side effects and you are not tolerating them, you should switch to a lower dose even after a week (single injection).

If after using Mounjaro 10 mg for 4 weeks your blood glucose level is still high, you can increase the dose after 4 weeks to 12.5 mg.

  • Can you switch from 5 mg directly to 10 mg Mounjaro?

Switching directly from 5 to 10 mg is not recommended. You can, however, switch directly in one condition from 5 to 10.

If you were previously on 10 mg and due to the non-availability of 10 mg or some other reasons you continued the 5 mg injections, in such situations, you can switch directly from 5 to 10 mg.

  • What is the maintenance dose of Mounjaro?

The maintenance dose is the dose on which your blood glucose is well controlled and you are tolerating it without side effects. It can be 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg.

However, you can not exceed 15 mg. In addition, the starting dose of 2.5 mg is not recommended to be continued as the maintenance dose.

  • What is the highest dose of Mounjaro?

The highest dose of Mounjaro is 15 mg per week.

  • How long do you stay on Mounjaro?

You can continue Mounjaro for as long as:

    • You afford it
    • Your blood glucose is well controlled with it
    • You are tolerating it

Since this is a relatively new drug, people have been using it for one year or so. Those who were in the clinical trials have continued it for more than a year.

For diabetes, Mounjaro starts working within hours. The peak plasma levels of the drug are achieved within 8 to 72 hours.

Although appetite suppression is achieved within days, its weight-loss effects may be noticed after a week or so.

  • How many doses per pen of Mounjaro?

Each pen contains 0.5 ml of the drug. Each pen is available in different strengths of 2.5 mg, 5, 7.5, 10, 12.5, and 15 mg.

One pen contains only one dose. You need 4 pens for a month.

  • What is the dose of Mounjaro for Diabetes?

The dose of Mounjaro for diabetes is 2.5 mg weekly for 4 weeks followed by 5 mg per week injection.

People who achieve their blood glucose targets with 5 mg can continue the 5 mg dose.

If the glucose targets are not achieved, the dose is escalated every 4 weeks by 2.5 mg per 4 weeks to the highest dose of 15 mg.

  • What is the dose of Mounjaro for Weight Loss?

The dosing schedule of Tirzepatide (Zepbound) is the same as mentioned for Mounjaro for diabetics but people will need to continue a higher maintenance dose if they are using it for weight loss for better results.

The best weight loss results may be achieved with doses ranging from 10 to 15 mg per week.

  • Can you skip Mounjaro Dose?

Skipping Mounjaro doses is not recommended. If you skip the dose, you will notice fluctuations in your blood glucose and you will not get the best results.

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Mounjaro Side effects:

  • What are the common side effects of Mounjaro?

The most common side effects of Mounjaro, reported in clinical trials were related to the stomach. These included:

  • Nausea: 12 to18 %
  • Diarrhea: 12 to 17%
  • Loss of appetite: 5 to 11%
  • Vomiting: 5 to 9 %
  • Constipation: 6 to 7 %
  • Dyspepsia: 5 to 8 %
  • Abdominal pain: 5 to 6%

Other less common side effects included abdominal distension, eructation, GERD, burping, and abdominal gases.

  • What are the serious side effects of Mounjaro?

Serious side effects that may need discontinuing Mounjaro include:

  • Pancreatitis
  • Kidney failure
  • Medullary thyroid cancer
  • Severe hypoglycemia
  • Severe allergic reactions such as anaphylaxis
  • Vision loss (Worsening diabetic retinopathy)
  • Gallstones and cholecystitis

In addition, it is contraindicated if you have a personal or a family history of medullary thyroid cancer or MEN-2 syndrome.

  • What are the long-term side effects of Mounjaro?

Some of the long-term side effects that may persist even if you discontinue the drug are:

  • Thyroid cancer (may persist for life)
  • Pancreatitis (may take weeks to months to recover. Some patients may develop complications of pancreatitis and have lifelong symptoms)
  • Gallbladder disease (Gallstones may persist for life unless treated. Symptoms of gallstones may come and go and remain for life)
  • Complications resulting from severe and recurrent hypoglycemia (recurrent hypoglycemia can lead to memory and cognitive impairment while severe hypoglycemia can lead to permanent brain damage)
  • Severe weight loss may take weeks to months to regain weight
  • Depression may persist for years or even for life

It is important to note that some side effects are short term but their complications can persist throughout the life of the person.

  • How long do Mounjaro’s side effects last?

Most GI side effects of Mounjaro such as nausea, burping, and abdominal fullness improve within weeks to months as the patient gets used to it.

However, other long-term side effects as mentioned above may persist for life.

  • What are thyroid-related side effects of Mounjaro?

Mounjaro, like all other GLP-1 analogs (Ozempic and others), is associated with a rare type of thyroid cancer called medullary thyroid cancer.

Mounjaro might interfere with the absorption of Levothyroxine and consequentially affect its efficacy.

Furthermore, if you experience significant weight loss while taking Mounjaro, it may be necessary to modify your Levothyroxine dosage.

  • Does Mounjaro cause thyroid cancer?

Yes. Mounjaro and Ozempic are associated with an increased incidence of medullary thyroid cancer.

It is specifically concerning in people with a personal or a family history of medullary thyroid cancer and those with MEN-2 syndrome.

Mounjaro is not directly associated with hair loss. However, hair loss has been increasingly noticed by people using Mounjaro especially those who lose significant weight and develop malabsorption.

Since hair growth requires vitamins such as biotin, zinc, vitamin C, iron, and other nutrients, Mounjaro users may develop a deficiency of these vitamins resulting in hair loss.

  • Does Mounjaro cause body aches and fatigue?

Body aches and fatigue are very non-specific symptoms. People using Mounjaro have reported these side effects more compared to those not using it.

Fatigue, lethargy, and body aches may develop if a person is not taking enough nutrients or not sticking to an exercise schedule.

  • How do you manage Mounjaro’s GI side effects like burping and nausea?

To minimize nausea, burping, abdominal pain, and other GI side effects of Mounjaro, it is recommended to take small meals, eat slowly, and avoid foods that cause bloating such as beans, pulses, and a diet rich in carbs, take low FODMAP diet, manage stress, and titrate the dose gradually.

In addition, you may take over-the-counter antacids like Gaviscon, Pepto-Bismol, and Sodium bicarbonate lozenges.

You may take ginger or peppermint tea and probiotics to help restore your gut flora.

  • How long do the side effects of Mounjaro usually last?

Most side effects of Mounjaro are very brief and resolved on their own once the person gets used to the drug.

However, some side effects may last for a longer time such as those who develop pancreatitis or kidney injury.

  • Can Mounjaro cause weight gain?

No. Mounjaro is associated with significant weight loss. If you are gaining weight with Mounjaro, you may be taking more calories than you burn or using other drugs that cause weight gain such as insulin, sulfonylureas, or antidepressants.

  • Can Mounjaro cause low blood sugar?

Mounjaro alone does not cause your blood sugars to go down a certain point (less than 100).

However, if you are using another drug with Mounjaro such as Insulin or sulfonylurea, your blood glucose may drop significantly.

You need to adjust your insulin dose when you start using Mounjaro.

  • Can Mounjaro (Tirzepatide) cause allergic reactions?

Yes. Allergic reactions have been observed in clinical trials. Allergic reactions may range from localized reactions such as skin redness, pain, induration, and itching to severe reactions such as shock and angioedema.

  • How often do people experience side effects when taking Tirzepatide?

The most common side effects of Mounjaro such as nausea, burping, constipation, and diarrhea are reported by 7 to 15% of the patients while the less common side effects are only reported by 2 to 3% of the patients.

  • What should I do if I experience side effects while taking Mounjaro?

Titrate the dose gradually and as recommended. Do not jump from 2.5 to 10 or 5 to 10 or from 10 to 15. Increase the dose by 2.5 mg every 4 weeks.

Take small meals. Eat slowly. Follow an exercise routine. If needed, take an OTC antacid or drugs like pepto-bismol. Drink ginger or peppermint tea after meals.

  • Does Mounjaro cause high blood pressure?

Mounjaro is not associated with high blood pressure. In fact, most patients may report low blood pressure because of dehydration and weight loss.

However, people who develop side effects and those who develop anxiety or depression may notice a rise in blood pressure.

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Mounjaro Efficacy in Diabetes:

  • How effective is Mounjaro for Diabetes compared to other diabetes medications?

According to the ADA, Mounjaro is the most potent diabetes drug. It is more potent than Ozempic and other diabetes medications.

It has been associated with a reduction in the A1C by up to 2.4% compared to 0.8% with Jardiance, 0.6% with Farxiga, 1% with Metformin, 1.2%  with Rybelsus, and 1.8% with Ozempic.

Both Ozempic and Mounjaro are excellent diabetes drugs. However, Mounjaro is superior to Ozempic in terms of its weight-losing and glucose-lowering effects.

Both drugs have the same side effects profiles, however, people with Mounjaro are more likely to develop diarrhea, pancreatitis, and raised lipase and amylase levels.

  • How much would your A1C drop after 3 months of using Tirzepatide (Mounjaro)?

The drop in A1C depends on multiple factors such as:

  • Your baseline A1C (if your baseline A1C is 9 or more, you would expect a greater drop compared to an A1C of 8 or less)
  • Your commitment to lowering your blood glucose (if you stick to a low-calorie diet and exercise daily, follow your doctor’s advice, and adjust your medications, your A1C will drop significantly, otherwise it will not work for you)
  • Concomitant medications (Some medicines such as corticosteroids and antipsychotics may not let Mounjaro drop your A1C to what you expect).

However, the average drop in A1C one would expect after 24 weeks is about 2.4%. This can range from 1.5 to 2.5%.

  • Can Mounjaro reverse Type 2 Diabetes?

Obese and overweight people with diabetes (diabesity) who lose significant weight may notice a marked decline in their insulin resistance and improvement in A1C.

Some patients may notice that they even do not require medications for diabetes anymore.

So, yes it can reverse diabetes in a subset of diabetic patients who are obese and newly diagnosed and who lose significant weight with Mounjaro.

Mounjaro is not recommended for use in Type 1 Diabetes. The use of GLP-1 and Mounjaro in morbidly obese Type 1 Diabetics is an area of investigation as these patients may have combined Type 1 Diabetes and Insulin resistance as well.

  • Is Mounjaro FDA-approved for prediabetes?

Mounjaro is not approved for the treatment of prediabetes. However, if approved for weight loss, people with prediabetes may benefit the most as it will delay the onset of diabetes when they lose significant weight.

  • Is Mounjaro an Insulin?

Mounjaro is not insulin. It is totally different from insulin both structurally as well as how these two drugs work.

However, the mode of administration of Insulin and Mounjaro is the same.

  • Can you use Mounjaro with Insulin and Metformin?

Yes. Mounjaro is usually prescribed with metformin. It can also be prescribed with Insulin, sulfonylureas (Glipizide, Glimepiride, Gliclazide, and Glyburide), SGLT2 Inhibitors (Jardiance and Farxiga), and thiazolidinediones (Pioglitazone).

  • Is Mounjaro better than Metformin for Diabetes?

Mounjaro and metformin are two different drugs. Both have different mechanisms of action and PROs and CONs.

Mounjaro is very effective for diabetes while metformin is also highly effective but inferior to Mounjaro in lowering A1C.

Mounjaro is also a potent weight loss drug compared to metformin. Mounjaro is too costly compared to metformin.

Metformin is a time-tested drug while Mounjaro is a newly approved medicine and its safety is not yet fully known when used on a long-term basis.

  • Can you use Mounjaro with Ozempic for Diabetes?

No. The combined use of Mounjaro and Ozempic is not recommended.

  • Can you use Mounjaro with Jardiance or Farxiga for Diabetes?

Yes. This is one of the best combinations as it lowers cardiovascular mortality, A1C, and body weight compared to other drug combinations.

  • Can you get Mounjaro without Diabetes?

Currently, Mounjaro is not approved for people without diabetes and your doctor can only prescribe it to you if you have diabetes.

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Effect on Body Weight:

  • Is Mounjaro FDA-approved for weight loss?

Yes, but with a different market name, Zepbound. Mounjaro is associated with greater weight loss compared to Wegovy, Saxenda, Contrave, Qsymia, and Xenical.

  • When was Mounjaro approved for weight loss?

8th November 2023.

  • How does Mounjaro work for weight loss?

Mounjaro suppresses your appetite. It also causes some degree of malabsorption and delays gastric emptying.

In addition, it alters the hunger signals going to the brain and satiety centers and reduces food cravings.

  • How quickly do you lose weight on Mounjaro?

The weight loss effects of Mounjaro may be observed as soon as within the first week of starting the treatment.

However, since the first four doses are only the priming doses, it may take a month or two for you to notice a change in your body weight.

  • How much weight can you lose with Mounjaro?

In clinical trials, an average of 24% body weight has been seen. This much weight loss has not been seen with any of the FDA-approved weight loss drugs including Ozempic (16%), Saxenda (11%), and Contrave (8%).

  • How much weight can you lose in a month with Mounjaro?

You may not lose significant weight during the first month because the dose used during the first month is too low as it is the starting dose so the person gets used to it and starts tolerating it.

The average weight loss per month with Mounjaro depends on the dose. However, you can expect a weight loss of 0.7 kg to 1.5 kg (1.5 to 2.2 lbs) in a month with Mounjaro.

  • How much weight per week can you lose with Mounjaro?

The average weight loss per week with Mounjaro can range from 0.2 kg (0.4 lbs) to 0.4 kg (0.8 lbs).

However, it all depends on the baseline weight, the dose of Mounjaro, and associated conditions.

In addition, people on a calorie-deficit diet and those who exercise can lose more weight compared to overeaters and people with genetic obesity.

  • How long can you take Mounjaro for weight loss?

You can continue Mounjaro as long as you are tolerating it and the drug is effective. In addition, cost may be one factor when people would like to switch back to a less costly medicine especially when they lose significant body weight.

Mounjaro and Bariatric surgery (gastric sleeve and gastric bypass) are two different modalities of treating obesity and obesity-associated medical conditions such as diabetes.

Mounjaro is a once-weekly injection and the most effective diabetes drug approved so far. It may also reverse diabetes.

However, gastric sleeve and gastric bypass are far more effective than Mounjaro for weight loss and reversing obesity-associated medical conditions like diabetes.

Mounjaro is associated with a weight loss of about 24% while Bariatric surgeries are associated with a weight loss of about 60%.

In addition, bariatric surgery is associated with a reversal of diabetes in about 60 to 80% of the patients.

  • Can you take Mounjaro for weight loss without diabetes?

Yes! Tirzepatide has been approved for weight loss as Zepbound.

  • Which is better Ozempic or Mounjaro for weight loss?

Mounjaro and Ozempic are similar as both are weekly injections and both mimic GLP-1 in the body. However, Mounjaro also activates GIP.

In clinical trials, Mounjaro resulted in a weight loss of 24% versus 16% with Semaglutide (Wegovy).

The results of the SURPASS 2 Trial which compared Mounjaro and Ozempic are summarized in the table below:

SURPASS-2 Trial: Tirzepatide Vs Ozempic 1 mg (Semaglutide)

 Mounjaro 5 mgMounjaro 10 mgMounjaro 15 mgSemaglutide 1 mg
Weight-7.6 kg-9.3 kg-11.2 kg-5.7 kg
  • At what dose of Mounjaro will you lose weight the most?

For weight loss, generally, higher doses are more effective. If you can tolerate a dose of 10 mg or more, you may lose weight the most.

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Mounjaro Vs Ozempic and other Weight Loss Drugs:

  • Which is better for weight loss: Ozempic or Mounjaro?

Ozempic and Mounjaro are both blockbuster drugs. However, Mounjaro is associated with more weight loss compared to Ozempic.

In clinical trials, weight loss associated with Ozempic was 16% max while with Mounjaro, it was about 24% max.

  • Which drug has been approved for weight loss without diabetes?

Mounjaro, Tirzepatide has been approved for weight loss under a different brand name, Zepbound.

Ozmepic is approved only for diabetes but its higher dose formulation, Wegovy, has been approved as a weight loss drug.

  • Is Mounjaro better than Metformin for weight loss?

Yes. Mounjaro is far superior to Metformin for weight loss. Metformin is considered a weight-neutral drug (it is not associated with weight loss or weight gain) while Mounjaro may let you lose one-fourth of your body weight.

  • Is Mounjaro better than Xenical (Orlistat) for weight loss?

Yes. Mounjaro is way superior to Xenical for weight loss. Xenical (orlistat) and Mounjaro are both associated with significant GI side effects.

However, you may lose weight about three to five times more with Mounjaro compared with Xenical.

  • Can you take Mounjaro and Xenical combined for weight loss?

Yes. There are no contraindications but you should be ready for the GI side effects as both drugs are associated with nausea, vomiting, diarrhea, bloating, burping, and abdominal gases.

  • Is Mounjaro better than Contrave for weight loss?

Yes. Mounjaro is superior to Contrave for weight loss. Mounjaro is associated with more than 20% weight loss while Contrave is associated with only 6% body weight loss.

  • Can you take Mounjaro and Contrave together for weight loss?

There is no harm in combining Mounjaro with Contrave especially if you are no more losing weight with Mounjaro. However, you may develop more side effects.

  • Can I take Phentermine and Mounjaro together?

Yes. But since Mounjaro is a very potent drug, you usually don’t need to take phentermine and add on to your side effects.

  • Can you use Mounjaro with Bupropion?

Yes. If your doctor advises you on an antidepressant or treatment for smoking cessation or ADHD, Bupropion may be considered the first choice as it supplements the weight loss effects of Mounjaro.

  • Can you use Saxenda with Mounjaro for weight loss?

No. Combining Saxenda and Mounjaro as well as other drugs acting as GLP-1 agonists are not recommended.

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Mounjaro Drug Interactions:

  • Does Mounjaro have any drug interactions?

Mounjaro may cause hypoglycemia when combined with insulin or other diabetes drugs especially sulfonylureas like Glipizide, Glimepiride, and Glyburide.

Mounjaro may increase your risk of pancreatitis if you are taking drugs like corticosteroids and other chemotherapeutic drugs which can cause pancreatitis too.

In addition, drugs that act on GLP-1 should not be used with Mounjaro including Ozempic, Saxenda, Victoza, Trulicity, Byetta, and DPP-IV inhibitors.

  • Can you take Mounjaro and Adderall together?

Yes. However, you are likely to develop stomach upset, heartburn, and abdominal pain if you take it for a longer time or more than a few doses.

  • Can you take Mounjaro and Zoloft together?

Yes. But you may not lose the amount of weight you expect with Mounjaro because Zoloft is associated with weight gain.

  • Can you take Zofran and Mounjaro together?

Yes. Zofran is used to reduce the symptoms of nausea, vomiting, and dyspepsia in patients on Mounjaro.

However, if you develop severe abdominal pain or your symptoms persist despite using Zofran, you should consult your doctor.

  • Can you take Mounjaro with other weight-loss drugs?

You can use Mounjar with Xenical (Orlistat), Contrave, and Qsymia but not with Wegovy and Saxenda.

  • Can you take Mounjaro with Diabetes drugs?

Yes, except for other GLP-1 analogs and DPP-IV inhibitors.

  • Can you use Mounjaro with Levothyroxine?

Yes, but you need to monitor your thyroid levels because you may see some fluctuations in your thyroid levels when you start using Mounjaro.

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Mounjaro Cost and Insurance:

  • What is the price of a Mounjaro Injection?

The average cost of Mounjaro is USD 1023 per 4 weeks of supply (equivalent to 4 injections).

  • How much does Mounjaro cost per month?

In the US, the average cost of Mounjaro is $1023 per month without insurance.

  • How much does Mounjaro cost per year?

The average per-year cost of Mounjar is estimated to be around $12,276.

  • Is Mounjaro covered by Insurance?

Yes. Some insurance plans do cover Mounjaro for the treatment of Diabetes.

  • How much is Mounjaro without Insurance?

Mounjaro is very costly without insurance. It is estimated to cost you $1023.

  • How to get Mounjaro covered by Insurance?

Before applying for insurance coverage, you must have diabetes and a valid prescription of Mounjaro by your doctor.

Next, you can check or call your insurance company to see if they cover Mounjaro or not.

  • How to activate the Mounjaro savings card?

You can visit the website and follow the steps. Alternatively, you can ask your pharmacist.

  • How to get Mounjaro for $25?

You can visit the website and activate your $25 card.

However, you must have a valid prescription of Mounjaro, you must be 18 years of age or older, and you must be a resident of the United States or Puerto Rico.

In addition, you must not be registered with another government-funded prescription program.

  • How to get a Mounjaro 12-month coupon?

You can search the Mounjaro website or visit any of the listed saving resources to get your 12-month coupon: Click on this link!

  • What is the cost of Mounjaro Injections in the US, Canada, Australia, UAE, Ireland, UK, Mexico, and other countries?

The table below is an estimated monthly price of 7.5 mg Mounjaro:


Price per month


United States$ 1023USD
MexicoMXN 6400Mexican Peso
Australia$ 900Australian Dollar
UK$300Sterling pound
CanadaCA 990Canadian Dollar
Ireland350 EurosEuros
IndiaINR 30000Indian Rupees
South AfricaZAR 6900South African Rand
Saudi ArabiaAED 1734Emirati Dirham
QatarQAR 1750Qatari Riyal
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I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

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