Semaglutide vs Dulaglutide is a comparison of the two novel GLP-1 analogs. Semaglutide is available in three formulations i.e Rybelsus, Ozempic, and Wegovy. Dulaglutide is only available as Trulicity Injection.
- Rybelsus is the oral tablet formulation available as 3 mg, 7 mg, and 14 mg tablets.
- Ozempic is available as 0.5 mg and 1.0 mg subcutaneous injections.
- Wegovy is available as a 2.4 mg once-weekly injection.
Before and After Pictures & Reviews of People who are using Ozempic
Trulicity is available as 0.75 mg and 1.5 mg subcutaneous once-weekly injections. These drugs exert their effects by acting as incretin mimetics.
Hence, they both cause the release of insulin and suppress glucagon in a glucose-dependent mechanism.
When glucose is elevated in the plasma, they cause the release of insulin and simultaneously suppresses glucagon levels.
These drugs also inhibit the motility of the stomach and delay gastric emptying.
This can cause nausea, vomiting, abdominal fullness, bloating, and suppresses the appetite. Thus, they may also have a weight-losing effect.
However, the FDA has approved Semaglutide only for the management of obesity. Dulaglutide is only approved for the management of diabetes.
WEGOVY (Semaglutide 2.4 mg once weekly) is FDA approved for Obesity
Table of similarities and differences between Semaglutide Vs Dulaglutide:
Semaglutide |
Dulaglutide |
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Drug Class | GLP-1 analog | GLP-1 analog |
Manufacturer’s Names | Novo Nordisk | Eli Lilly |
Brand names |
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Formulations available |
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Indications | FDA approved for Diabetes and Obesity |
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Cost Comparison |
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Pharmacokinetics Comparisons of Semaglutide Vs Dulaglutide:
Semaglutide |
Dulaglutide |
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Peak Plasma concentrations | 1 – 3 days after a single dose | 24 to 72 hours |
Half-life elimination | One week (It stays in the body for about 5 weeks) | Five days |
Excretion/ Metabolism | Excreted in Urine and feces | It is metabolized into amino acids in the body |
Administration | The oral tablet is administered once daily after meals. The injections are administered once-weekly as a subcutaneous injection | It is administered once weekly subcutaneously into the anterior abdomen. |
Comparing the efficacy of Semaglutide Vs Dulaglutide in Diabetic and Obese Individuals:
Semaglutide |
Dulaglutide |
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Efficacy in Diabetes |
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Weight loss effects |
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Side effects |
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In Summary:
Semaglutide (Rybelsus, Ozempic, and Wegovy) has a superior weight-losing effect compared to Trulicity (Dulaglutide).
Semaglutide is also more efficacious than Dulaglutide in terms of glycemic control.
Both Semaglutide and Dulaglutide are available as a once-weekly injection formulation, however, only Semaglutide is available as once-daily oral tablets.
Dulaglutide (Trulicity) is much cheaper than Semaglutide injections (Ozempic).