Jardiance Vs Glipizide: Which is Better?

Jardiance (Empagliflozin) and Glipizide are two medications that are commonly used in the treatment of type 2 diabetes.

While they belong to different classes of medications, they share the goal of managing blood sugar levels in patients with diabetes.

Here is a general comparison of Jardiance and Glipizide:

Comparison	Jardiance (Empagliflozin)	Glipizide
Class	SGLT2 Inhibitor	2nd Generation Sulfonylurea
FDA Approval	1st August 2014	08th May 1984
Requires Prescription	Yes	Yes
Bioavailability	100%	100%
Protein binding	86.2%	98%
Half-life	12.4 hours	4.3 hours
Excretion	Renal (74%)	Renal (80%)
Duration of action	24 hours	24 hours

We will compare the pros and cons of Jardiance Vs Glipizide to help patients and healthcare providers make informed decisions about which medication is best for them.

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Jardiance Vs Glipizide:

• Indications:

Jardiance is approved by the FDA for the treatment of type 2 diabetes and heart failure. In contrast, Glipizide is approved only for the treatment of type 2 diabetes.

Thus, Jardiance may be a better option for patients with both type 2 diabetes and heart failure.

• Dosage and Formulation:

Jardiance is available as an oral tablet that is taken once daily after breakfast, whereas Glipizide is available as an immediate or delayed-release oral tablet that is taken once or twice daily before meals.

The once-daily dosing of Jardiance and GLipizide may make these drugs more convenient for some patients to adhere to their medication regimen.

Additionally, Jardiance and Glipizide are available only as oral tablets, making these drugs a good option for patients who do not like injections (insulin and GLP-1 analogs).

• Effect on Weight:

Jardiance has been shown to lower body weight, while Glipizide may cause weight gain. This can be a significant factor for patients who are overweight or obese.

• Efficacy in Diabetes:

Both Jardiance and Glipizide are effective in lowering blood sugar levels. However, Glipizide has been shown to lower A1C by a higher percentage (1-2%) than Jardiance (0.8%).

According to the ADA, Jardiance is an “intermediate-potency oral diabetes drug” while Glipizide is a “high potency oral diabetes drug”.

Glipizide is an alternative option for people who are reluctant to use injectable medicines, especially insulin.

• Compatibility:

Jardiance can be used with all diabetes medications except other drugs from the same class. In contrast, Glipizide is not compatible with insulin secretagogues (sulfonylureas, Meglitinides) and insulin.

This means that patients who are taking insulin or insulin secretagogues may need to switch to a different medication if they wish to use Glipizide.

• Use in Heart Patients:

Jardiance is approved for heart failure in diabetic as well as non-diabetic patients, while Glipizide is neutral in cardiac and renal diseases.

Thus, Jardiance may be a better option for patients with both type 2 diabetes and heart failure.

• Hypoglycemia:

Jardiance does not cause hypoglycemia, while Glipizide increases the risk of hypoglycemia. Hypoglycemia is a potentially dangerous side effect that can occur when blood sugar levels drop too low.

• Cost:

Jardiance is more expensive than Glipizide, with a cost of USD 21.14 per tablet compared to USD 0.34 per tablet for Glipizide. However, cheaper generics of Glipizide are available.

• Other Considerations:

Jardiance has been associated with an increased risk of urinary and genital infections and may cause excessive urination.

Glipizide is a good option for those who don’t like injections (insulin and GLP-1 analogs) and is covered by insurance.

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Table summarizing the Pros and Cons of Jardiance Vs Glipizide:

Comparison	Jardiance (Empagliflozin)	Glipizide
Indications	Type 2 Diabetes Heart failure	Type 2 Diabetes
Dosage	Once daily after breakfast	Once daily (or twice daily before meals)
Formulation	Oral	Oral (immediate and delayed-release tablets)
Effect on Weight	Lowers body weight	May cause weight gain
Efficacy in Diabetes	Lowers A1C by 0.8%	Lowers A1C by 1 – 2%
Compatibility	All diabetes medications except other drugs from the same class	Not compatible with insulin secretagogues (sulfonylureas, Meglitinides) and insulin
Use in heart patients	Approved for heart failure in diabetic as well as non-diabetic patients	Neutral in cardiac and renal diseases
Hypoglycemia	Does not cause hypoglycemia	Increased risk of hypoglycemia
Cost	USD 21.14 per tablet	USD 0.34 per tablet
Other	Increased risk of Urinary and genital infections May cause excessive urination	Cheaper generics are available. A good option for those who don’t like injections (insulin and GLP-1 analogs) Covered by insurance

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In conclusion:

Jardiance and Glipizide are two widely used drugs for the treatment of type 2 diabetes. Both drugs have their own set of advantages and disadvantages.

Jardiance is a more effective drug in terms of weight loss and cardiovascular benefits, but it is associated with an increased risk of urinary and genital infections.

On the other hand, Glipizide is a more affordable drug and is more potent than Jardiance in lowering A1C, but it can cause weight gain and increase the risk of hypoglycemia.

Jardiance can be used with any of the diabetes medicines except for drugs from the same class. Glipizide can not be used together with insulin, or insulin secretagogues such as meglitinides and sulfonylureas.

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