in ,

Bexagliflozin FDA Approved for Diabetes: TheracosBio Brenzavvy

Bexagliflozin FDA Approval

Bexagliflozin brenzavvy fda approval

On 20th January, the FDA approved a new SGLT2 inhibitor, Bexagliflozin for the treatment of adults with Type 2 Diabetes [Ref].

The drug is a brand of TheracosBio by the name of Brenzavvy.

Bexagliflozin is the 5th SGLT2 inhibitor that the FDA approved for the treatment of adults with Diabetes Type 2. The other SGLT2 inhibitors that have been approved and are very commonly used are:

Bexagliflozin was approved in December 2022 for the treatment of Diabetes in cats.

You may also like to read:

How effective is Brenzavvy Vs other SGLT2 Inhibitors?

According to the ADA 2023 guidelines, SGLT2 inhibitors are classified as “intermediate to highly potent” diabetes medicines.

The following table summarizes diabetes drugs based on their potency:

Efficacy of Type 2 Diabetes Medications (in descending order)



Intermediate DPP-IV Inhibitors
  • Sitagliptin
  • Vildagliptin
  • Linagliptin
  • Alogliptin
  • Saxagliptin
Intermediate to high SGLT2 Inhibitors
  • Dapagliflozin
  • Empagliflozin
  • Canagliflozin
  • Ertugliflozin
High Metformin
  • Metformin
  • Pioglitazone
2nd Generation Sulfonylureas
  • Glyburide
  • Gliclazide
  • Glimepiride
High to very highly effective GLP-1 Receptor agonists
  • Dulaglutide
  • Liraglutide
  • Semaglutide
  • Exenatide
  • Insulin analogs
  • Human Insulin
Very high potency GIP and GLP-1 Receptor agonists
  • Tirzepatide

Among the SGLT2 inhibitors, Canagliflozin is the most potent, followed by Ertugliflozin, Empagliflozin, and Dapagliflozin.

You may also like to read:

The A1C reduction of different SGLT2 inhibitors is tabulated below:

SGLT2 Inhibitor


Percentage A1C reduction

Canagliflozin 100 mg 0.91%
300 mg ↓ 1.16%
Empagliflozin 10 mg ↓ 0.7%
25 mg ↓ 0.8%
Ertugliflozin 5 mg ↓0.6%
15 mg ↓ 0.7%
Dapagliflozin 5 mg ↓0.6%
10 mg ↓ 0.7%
Bexagliflozin 20 mg ↓ 0.5%

SGLT2 inhibitors are categorized based on their potency (Data is taken from the FDA-prescribing information of each drug):

SGLT2 Inhibitor


Percentage A1C reduction

Canagliflozin 300 mg ↓ 1.16%
Canagliflozin 100 mg ↓ 0.9%
Empagliflozin 25 mg ↓ 0.8%
Empagliflozin 10 mg ↓ 0.7%
Ertugliflozin 15 mg ↓ 0.7%
Dapagliflozin 10 mg ↓ 0.7%
Ertugliflozin 5 mg ↓ 0.6%
Dapagliflozin 5 mg ↓ 0.6%
Bexagliflozin 20 mg ↓ 0.5%

Since Bexagliflozin (Brenzavvy) is one of the least potent SGLT2 inhibitors, it might not be able to compete with other SGLT2 inhibitors.

In addition, Bexagliflozin (Brenzavvy) is contraindicated in patients with kidney disease and not recommended in patients with a CrCl of less than 30 ml/minute.

Thus, although approved by the FDA for the treatment of diabetes, it may not win the markets.

Additional studies may be needed to see the full therapeutic response of the drug.

Lastly, if the price is kept the lowest, it may be utilized by physicians for their patients who are paying from their pockets or in low-income countries.

You may also like to read:

What do you think?

Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

Here is a link to My Facebook Page. You can also contact me by email at or at My Twitter Account
You can also contact me via WhatsApp 🙏

Brenzavvy (bexagliflozin) 20 mg tablets

Bexagliflozin (Brenzavvy): FDA Prescribing Information

african mango for weight loss

African Mango for Weight Loss and Side effects: Irvingia