Semaglutide and Intermittent fasting have additive effects in reducing body weight and controlling blood glucose.
Intermittent fasting is probably much easier to practice with Semaglutide than without Semaglutide.
Since individuals on Semaglutide feel full most of the time and don’t have the urge to eat, intermittent fasting becomes much easier.
Here is one review …
In addition, intermittent fasting might alleviate some of the gastrointestinal symptoms of Semaglutide (Ozempic, Wegovy, and Rybelsus).
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Weight Loss With Semaglutide and Intermittent Fasting:
Semaglutide is associated with significant weight loss ranging from 10 to 16% in clinical trials. Real-life users have reported even greater weight loss.
Intermittent fasting is associated with 3.5% body weight loss in six months in a recent study. Other studies have reported a weight loss of 7 to 11 lbs [Ref].
The combination of Semaglutide and Intermittent fasting can have additive effects.
Here are some of the individual testimonials who practiced intermittent fasting with Semglutide:
Lost 55 lbs in 5.5 months with Semaglutide and Intermittent Fasting
I am on 7 mg Rybelsus and 16:8 Intermittent Fasting Schedule
Lost 20 lbs in 5 weeks with Semaglutide and Intermittent Fasting
Lost 18% body weight with Wegovy and 16:8 Intermittent Fasting Schedule
Sugar Control With Semaglutide and Intermittent Fasting:
Semaglutide is primarily a “Diabetes Medicine“. Ozempic and Rybelsus have been approved for managing Type 2 Diabetes.
Wegovy is approved for managing obesity in individuals with or without diabetes.
Ozempic is the second most potent diabetes medication after Mounjaro. It lowers the A1C by 1.8%. Rybelsus is the oral form. It lowers the A1C by 1.2%.
Intermittent fasting also improves Insulin sensitivity and glucose utilization. In a recent study, it was associated with 0.9% A1C reduction [Ref]
The combined effects of Semaglutide and Intermittent fasting can lead to better glucose control and A1C reduction.
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Side Effects of Semaglutide and Intermittent Fasting:
One of the common side effects of Semaglutide is “feeling full” all the time. This side effect is utilized in obese and diabetic individuals who have cravings for food and those who are non-compliant with dietary advice.
Intermittent fasting involves “abstaining from eating for a set period.” Nevertheless, individuals dealing with diabetes and obesity often find intermittent fasting to be a challenging undertaking.
People using Semaglutide find it easier to fast than those using insulin or other diabetes medications because of their hypoglycemic potential and tendency to feel hungry all the time.
In addition, increasing the time interval between two meals may reduce the side effects of Semaglutide.
Thus, practicing intermittent fasting, not only is easy, but it’s also practical as people can better tolerate Semaglutide.
It’s important to exercise caution regarding the potential for hypoglycemia, especially when using other diabetes medications, particularly insulin, along with Semaglutide.
Other Benefits of Semaglutide and Intermittent Fasting:
Semaglutide is a new drug and it is still being studied in metabolic and inflammatory conditions.
It has been found to exert a favorable effect on gut health in patients with Inflammatory Bowel Disease, IBS, Osteoarthritis, and Alzheimer’s.
In addition, it has been found to have a significantly positive effect on patients with alcohol use disorder. In fact, Semaglutide is a potential new drug for treating alcohol use disorder.
Semaglutide and Intermittent fasting, both improve insulin sensitivity, pancreatic function, and improve hormonal irregularities.
Here is a list of other benefits of Semaglutide and Intermittent fasting:
Benefits of Semaglutide and Intermittent Fasting | Semaglutide | Intermittent Fasting |
Regulates blood sugar levels | ✔✔✔ | ✔ |
Promotes weight loss | ✔✔✔ | ✔ |
Lower cardiovascular risk | ✔ | ✔ |
Lower risk of hypoglycemia | ✔ | ✔ |
Reduces appetite | ✔✔✔ | ✔ |
Enhances insulin sensitivity | ✔✔ | ✔✔ |
Associated with brain health | ✘ | ✔ |
Effect on longevity benefits | ✘ | ✔ |
Reduce inflammation | ✔ | ✔✔ |
Affects hormonal regulation | ✔ | ✔ |
Suitable for long-term | ✔ | ✔ |
In Conclusion:
Semaglutide and Intermittent fasting can help you lose more weight, and control your blood glucose better without added side effects.
People on Semaglutide better tolerate Intermittent fasting. However, one should keep an eye on blood sugars to avoid hypoglycemia.