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Is Semaglutide and Intermittent Fasting Safe and Effective?

Semaglutide and Intermittent Fasting

Semaglutide and Intermittent fasting have additive effects in reducing body weight and controlling blood glucose.

Intermittent fasting is probably much easier to practice with Semaglutide than without Semaglutide.

Since individuals on Semaglutide feel full most of the time and don’t have the urge to eat, intermittent fasting becomes much easier.

Here is one review …

Semaglutide is like my secret weapon for fasting – I’ve gone from 16:8 to 20-4! Two months in, and I’ve already lost a cool 10 pounds.

In addition, intermittent fasting might alleviate some of the gastrointestinal symptoms of Semaglutide (Ozempic, Wegovy, and Rybelsus).

Weight Loss With Semaglutide and Intermittent Fasting:

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Semaglutide is associated with significant weight loss ranging from 10 to 16% in clinical trials. Real-life users have reported even greater weight loss.

Intermittent fasting is associated with 3.5% body weight loss in six months in a recent study. Other studies have reported a weight loss of 7 to 11 lbs [Ref].

The combination of Semaglutide and Intermittent fasting can have additive effects.

Here are some of the individual testimonials who practiced intermittent fasting with Semglutide:

Lost 55 lbs in 5.5 months with Semaglutide and Intermittent Fasting

Semaglutide with Intermittent fasting has been a total game-changer for me! I’ve been in this for 5.5 months, and I’ve lost a remarkable 55 pounds. I can easily switch between 16:8 and 18:6.


I am on 7 mg Rybelsus and 16:8 Intermittent Fasting Schedule

Rybelsus and Intermittent Fasting helped me shed pounds quickly at first, around 3 pounds a week, but as your body gets used to it, the weight loss slows down. Right now, I’m only dropping about 0.5 pounds per week.


Lost 20 lbs in 5 weeks with Semaglutide and Intermittent Fasting

I am on Intermittent Fasting, a 16:8 schedule along with a Calorie Restriction of 1000 to 1200 kcal per day. It’s been about 5 weeks on Semaglutide and I have already lost 20 lbs.


Lost 18% body weight with Wegovy and 16:8 Intermittent Fasting Schedule

I’ve been practicing 18:6 intermittent fasting for about 3-4 months and using Wegovy.
Surprisingly, I’ve lost more weight than my doctor expected, with a significant 18% reduction in body weight.

Sugar Control With Semaglutide and Intermittent Fasting:

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Semaglutide is primarily a “Diabetes Medicine“. Ozempic and Rybelsus have been approved for managing Type 2 Diabetes.

Wegovy is approved for managing obesity in individuals with or without diabetes.

Ozempic is the second most potent diabetes medication after Mounjaro. It lowers the A1C by 1.8%. Rybelsus is the oral form. It lowers the A1C by 1.2%.

Intermittent fasting also improves Insulin sensitivity and glucose utilization. In a recent study, it was associated with 0.9% A1C reduction [Ref]

The combined effects of Semaglutide and Intermittent fasting can lead to better glucose control and A1C reduction.


Side Effects of Semaglutide and Intermittent Fasting:

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One of the common side effects of Semaglutide is “feeling full” all the time. This side effect is utilized in obese and diabetic individuals who have cravings for food and those who are non-compliant with dietary advice.

Intermittent fasting involves “abstaining from eating for a set period.” Nevertheless, individuals dealing with diabetes and obesity often find intermittent fasting to be a challenging undertaking.

People using Semaglutide find it easier to fast than those using insulin or other diabetes medications because of their hypoglycemic potential and tendency to feel hungry all the time.

In addition, increasing the time interval between two meals may reduce the side effects of Semaglutide.

Thus, practicing intermittent fasting, not only is easy, but it’s also practical as people can better tolerate Semaglutide.

It’s important to exercise caution regarding the potential for hypoglycemia, especially when using other diabetes medications, particularly insulin, along with Semaglutide.


Other Benefits of Semaglutide and Intermittent Fasting:

Semaglutide is a new drug and it is still being studied in metabolic and inflammatory conditions.

It has been found to exert a favorable effect on gut health in patients with Inflammatory Bowel Disease, IBS, Osteoarthritis, and Alzheimer’s.

In addition, it has been found to have a significantly positive effect on patients with alcohol use disorder. In fact, Semaglutide is a potential new drug for treating alcohol use disorder.

Semaglutide and Intermittent fasting, both improve insulin sensitivity, pancreatic function, and improve hormonal irregularities.

Here is a list of other benefits of Semaglutide and Intermittent fasting:

Benefits of Semaglutide and Intermittent Fasting


Intermittent Fasting

Regulates blood sugar levels✔✔✔
Promotes weight loss✔✔✔
Lower cardiovascular risk
Lower risk of hypoglycemia
Reduces appetite✔✔✔
Enhances insulin sensitivity✔✔✔✔
Associated with brain health
Effect on longevity benefits
Reduce inflammation✔✔
Affects hormonal regulation
Suitable for long-term

In Conclusion:

Semaglutide and Intermittent fasting can help you lose more weight, and control your blood glucose better without added side effects.

People on Semaglutide better tolerate Intermittent fasting. However, one should keep an eye on blood sugars to avoid hypoglycemia.


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Best Intermittent Fasting Schedule: 16:8

What do you think?

Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

Here is a link to My Facebook Page. You can also contact me by email at or at My Twitter Account
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