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Linzess Pros and Cons: Linaclotide for IBS and CIC

Linzess pros and cons

ibs pros and cons linaclotide

Linzess pros and cons for the treatment of patients with IBS (irritable bowel syndrome) and patients with CIC (chronic idiopathic constipation) are discussed here.

A detailed FDA prescribing information regarding dosage and side effects is discussed elsewhere and can be viewed here:

[Linaclotide FDA Prescribing information]

A brief overview of Linzess:

Linzess or Linaclotide is a new drug that is used to treat the two very common medical conditions:

  • IBS-C (irritable bowel syndrome with constipation), and
  • CIC (chronic idiopathic constipation)

The one symptom common between these two conditions is constipation. So, basically, Linzess softens the stools by increasing the water content of the stools.

It does so by acting locally on the intraluminal gut epithelial cells activating the GCC receptors. This results in the secretion of chloride and bicarbonate-rich fluid into the intestinal lumen by the chloride channels.

Linzess (Linaclotide) for Weight Loss and IBS with Constipation

Linzess also activates the smooth muscles of the intestine and increases the peristaltic movements of the gut, thereby increasing the gut motility.

Another important function of Linzess that is especially helpful in patients with IBS is that it acts on the intraluminal visceral nerve endings and reduces the pain associated with IBS.

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Linzess Pros and Cons:

Linzess Pros and Cons are compared here with other laxatives and stool softeners. It is one of the newly approved medicines used to treat constipation and IBS [Ref]

Linzess Pros:

Linzess (Linaclotide) acts locally and does not get absorbed. Since it does not get into the systemic circulation, it is associated with minimal systemic side effects.

Linzess (Linaclotide) relieves constipation by increasing gut motility as well as increasing the water content of the stools. Since it has a dual action, it is more potent than most drugs that are used to treat constipation.

How to Get Relief from Ozempic-Induced Constipation

Unlike most other laxatives, Linzess does not only relieve constipation, it also acts on the local nerve endings and relieves visceral pain associated with constipation and IBS.

Most other laxative drugs are usually administered two to three times a day. However, Linzess is taken once daily before breakfast. The once-daily dosing is easy for most patients.

Linzess Cons:

Linzess is considered a very safe medicine, however, in children, especially younger than 6 years of age, it can cause severe diarrhea and dehydration.

It is not recommended to be used in individuals who are younger than 18 years of age and is contraindicated in children 6 years of age or younger.

Younge children may develop severe diarrhea resulting in dehydration. These children may require hospitalization for intravenous fluid administration to prevent kidney injury and hypotension.

Ozempic-Induced Diarrhea After Eating (Post-prandial Diarrhea)

Also, the postmarketing data from Linzess shows that it may cause bleeding from the gut which can be very disturbing for patients.

Linzess is not available OTC (over the counter) and one has to get a prescription for Linzess to get it from a pharmacy. This is not the case with most other stool softeners and laxatives.

Linzess has not been studied in pregnant and breastfeeding females. Although it acts locally, since data is not available to prove its safety in pregnancy and breastfeeding, it is not recommended. Pregnant females and breastfeeding mothers however can use most other OTC stool softeners.

Linzess Withdrawal Symptoms: Constipation, Abdominal Pain

Linaclotide is available only as two generic brands: Linzess and Costella. It is not available everywhere. Other laxatives are available worldwide.

Linzess is too costly. A monthly dose of Linzess costs about USD $500 or more. Other laxatives are more than 100 times cheaper than Linzess.

Table summarizing Pros and Cons of Linaclotide:

Linzess Pros

Linzess Cons

It acts locally and has fewer side effects It may cause severe diarrhea and dehydration in children
It has a dual-action It may cause GI bleeding
It relieves intestinal pain It is not recommended for pregnant and nursing mothers
It is administered once daily It has only two available brands and is not available everywhere
It can be administered via NG tube It is very costly

What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese, have diabetes, hypertension, high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.

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