Motegrity Weight Loss or Prucalopride-associated weight loss has not been adequately studied in clinical trials. It has been associated with the perception of weight loss, though.
How does Motegrity Work?
Motegrity or Prucalopride is a 5 HT-4 receptor activator. 5 HT4 are a subtype of serotonin receptors that are present in abundance in the intestinal tract.
Activation of these specific types of serotonin receptors enhances gut motility. Thus, this novel class of medicines is used primarily in the treatment of chronic constipation.
How does Motegrity Affect Changes in Body Weight?
As Prucalopride acts primarily in the intestinal serotonin receptors, most of its side effects are related to the gastrointestinal tract.
Most gastrointestinal GI side effects are associated with changes in body weight.
Individuals who have been on Motegrity (Prucalopride) have reported mixed symptoms of weight loss, weight gain, and no change in weight.
The effect of Motegrity on bodyweight has not been evaluated in clinical trials. In one study, for patients who had diabetes or connective tissue associated with gastroparesis, treatment with Prucalopride resulted in an increased perception of weight loss [Ref].
Although weight loss was not clinically documented, patients reported that they lost weight with Prucalopride.
Motegrity (Prucalopride) associated weight loss could be a result of any of the following effects of Prucalopride:
Motegrity impairs absorption:
- Serotonin receptor activation may increase intestinal motility and might affect the absorption of food. Loss of calories from the GI tract may be associated with weight loss
Motegrity suppresses appetite:
- One of the side effects of Motegrity is loss of appetite. A reduced appetite is directly associated with reduced food intake. Less food intake will cause a gradual weight loss.
People on social media have reported up to 50 lbs of weight loss with Motegrity. Most of the weight loss reported with Motegrity occurred during the first three months.
In addition, people who reported weight loss associated it with an improvement in wellbeing, bloating, and constipation.
However, the Motegrity weight loss effect lasted only a short while after which patients regained their body weight.
Weight loss associated with Motegrity is probably a result of better well-being, better eating habits, and exercise rather than a direct effect of Motegrity.
However, the weight loss effects of Prucalopride need to be investigated.