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High Protein High Fat Diet (High Protein Ketogenic Diet)

High Protein High Fat Diet

A high protein, high fat diet is a variation of the strict ketogenic diet. The ketogenic or keto diet is one that consists of 70% calories from fat, 20% calories from protein, and 5% from carbohydrates.

This typical form of the keto diet is much more difficult to follow. So, an easier variation of the keto diet is a high-protein high-fat diet which is also called a high-protein ketogenic diet.

This diet adds approximately 120 grams of protein and 130 grams of fat per day while the carbohydrates are limited to less than 10% of the total daily caloric intake. This modified version of the keto diet is simpler and requires less effort. The only side effect of this diet is that like carbohydrates, protein is also converted to glucose. This might cause a delay in ketosis but weight loss usually occurs if it is properly followed. In this article, we will discuss the effects of a high-protein high-fat diet on weight loss and some easy meals that go with this diet.

High Protein Ketogenic Diet vs Standard Ketogenic Diet:

keto diet fad diets high protein high fat diet A high-protein ketogenic diet, as the name implies, is in the form of a keto diet that demands eating a greater percentage of protein alongside fat. The macronutrient ratio comparison of both diets is as follows:
  • The standard ketogenic diet consists of 75% fat, 15-20% protein, and 5-10% carbohydrates.
  • The high protein ketogenic diet or high protein high-fat diet consists of 60-65% fat, 30% protein, and 5-10% carbohydrates.
This is clear that in this diet, the daily fat intake falls and protein intake increases. That means instead of consuming 50-60 g of protein daily. You might need to consume about 120-130 g of protein daily. While the carbohydrate consumption rate is the same in both diets.

High Protein Ketogenic Diet’s Effect on Weight Loss:

This type of diet keeps your blood sugar levels in check as it is low in carbohydrates, provides long-lasting energy, and reduces food intake and cravings by decreasing the production of hunger and appetite-stimulating hormones. Protein is well known for maintaining satiety. When protein food enters the small intestine, the gut hormone CCK signals the brain to reduce food intake. Appetite is suppressed till the protein or fat is present in the intestine. In this way, a high-protein high-fat meal aids in appetite suppression and ultimately weight loss. A study on 17 obese men studied the effects of a high-protein ketogenic diet on hunger, appetite, and weight loss. the study results showed that a low-carb, high-protein ketogenic diet has greater effects on weight loss and appetite suppression as compared to a moderate carb, low-protein non-ketogenic diet. [Ref]

High Protein High Fat Diet – Keto Diet and Ketosis:

Ketosis is a state in which ketone bodies are excreted in the urine. This state occurs when you eat less than 50 grams of carbohydrates in 3 days. Ketosis is the main mechanism for weight loss in the keto diet because it leads to the removal of body fat. With a high-protein ketogenic diet, ketosis becomes harder to achieve because the protein is also converted to glucose. It varies how quickly people attain ketosis after starting the keto diet, although it could a day in some people and might take up to 3 days in others. This variation is mainly because everyone’s metabolism of proteins and fats is different, and the body can attain a state of ketosis at varied based on hydration state, medications, and even stress levels. So, with a high protein keto diet, ketosis might be delayed for 2 to 3 days, but weight loss still occurs.

Foods to Eat on a High Protein High Fat Diet (Keto Diet):

high protein high fat diet keto diet While following a high protein keto diet, the foods are almost the same as on the standard ketogenic diet. Only an extra amount of protein is added. Foods allowed on an HPKD (high protein keto diet) include:
  • Healthy fats: olive oil, canola oil, sunflower oil, butter, tallow, etc.
  • High biologic value protein: Lean meats, eggs, nuts, seeds, poultry, and fish
  • Non-starchy vegetables: leafy green vegetables, tomatoes, cucumber, onions, asparagus, etc.

Foods to limit:

Foods restricted on this diet include high carbohydrate foods such as:
  • Bread and bakery items
  • Sugar and sugary beverages
  • Pasta
  • Starchy vegetables
  • Grains and grain products
  • Fruits
  • High carb sauces
  • Ready-to-eat foods
  • Alcoholic beverages

Benefits of following a High Protein Keto Diet:

The main advantage of this diet is that it is simpler and easier to follow as compared to a ketogenic diet. On a keto diet, people find it very difficult to consume fat in such high amounts daily. This modification provides them with ease by eating more protein and less fat than the standard ketogenic diet. This diet has also been reported to cause significant weight loss among obese people. Men are more likely to follow a high protein keto diet because they particularly eat greater amounts of protein as compared to women so, they find it easier than cutting out so much of their daily protein. Another benefit of this type of diet is that it keeps you away from consuming extra sugary foods, processed foods, and beverages. It also aids in maintaining blood sugar levels within the normal ranges.

Possible side effects of a high protein high-fat diet:

The most common disadvantage seen among people following a high protein keto diet is that the extra protein is converted to glucose and ketosis is delayed.

Health risks of a high-protein high-fat diet:

some conditions in which this type of diet must not be followed include:
  • People with high cholesterol levels must avoid such kinds of diets because there lies an increased risk of heart disease.
  • People with kidney disease must maintain their protein in low ranges, extra protein puts additional load and declines kidney function. So, these diets that are high in protein must be strictly avoided.
  • If you have osteoporosis or kidney stones, such diets might cause excessive loss of calcium which further aggravates the condition.
  • People with type 1 or type 2 diabetes mellitus should also be careful while following such diets.
Should the keto diet help you lose more weight if you are also on Ozempic? This seems like a good combination for weight loss, however, before you switch to a keto diet, you should know the pros and cons of combining the keto diet and Ozempic!

What is a Keto Diet?

The Keto diet is basically a high-fat and low-carb diet. When our body utilizes fats as energy, ketone bodies are released as a byproduct. The three most common ketones in our body are:
  • Acetone
  • Acetoacetate, and
  • Beta-Hydroxybutyrate
A keto diet is generally used by people who plan to lose weight. A typical ketogenic diet consists of four parts of fats and one part of the protein. The fats are primarily long-chain fatty acids. The modified keto diet consists of three parts of fats and one part of the protein. Medium-chain triglycerides substitute the fatty part. This is in contrast to the typical Western and Canadian diets that are composed of 48% Carbohydrates, 32% fats, and 17% proteins [Ref]. The ketogenic diet, apart from its weight loss effects, is best for children with epilepsy. It has also been studied in neurodegenerative diseases like Alzheimer’s disease and dementia.

Does a Keto Diet help you lose weight?

Smaller studies have exaggerated its weight loss effects, however, studies from larger randomized clinical trials have not shown a keto diet to be superior to a simple low-caloric diet. One Review article concluded that a keto diet might help you lose weight. At the end of one year, a difference of 2 kgs was noted in the keto diet group vs the low-fat diet group. More individuals in the keto-diet group lost weight compared to the low-fat diet group. Weight loss on a keto diet has been observed to be greatest at month 5. After that, the weight loss may be sustained for a year and regained thereafter. The weight loss associated with a keto diet is not universal. Individual participants may lose up to 30 kgs or even gain up to 10 kgs [Ref]. Weight loss of up to 10 lbs has been observed especially during the first two weeks. This initial weight loss effect of a keto diet is attributed to the diuretic effect of the keto diet.
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What are the health hazards of a ketogenic diet?

It is important to understand that a ketogenic is generally not considered a natural diet. Deviation from nature is always associated with side effects some of which may be very serious. A keto diet should not be used by the following people:
  • People with pancreatitis
  • Liver failure
  • People with diseases that alter fat metabolism
  • People with certain genetic diseases like pyruvate kinase deficiency, carnitine translocase, and carnitine palmitoyltransferase deficiency
  • Primary Carnitine deficiency
In addition, people with diabetes are at risk of developing hypoglycemia especially if they are on insulin or sulfonylureas. There are case reports of people developing DKA (diabetic ketoacidosis), a serious and life-threatening emergency that manifests as:
  • high blood glucose levels
  • the blood becomes acidic, and
  • ketone bodies formation
People on a ketogenic diet may also have a false-positive alcohol breath test. Also, a keto diet is associated with high cholesterol levels in the blood. Side effects due to the change in time may be severe in some cases. Keto flu is a term used to describe the initial keto-diet-related side effects that include:
  • Fatigue and lethargy
  • insomnia
  • Constipation
  • Nausea and vomiting
  • Dizziness
  • headache, and
  • exercise intolerance
People are usually advised to take adequate water and supplements to cover the side effects associated with the keto diet.

Should you follow a keto diet when using Ozempic?

When using Ozempic, especially for weight loss and diabetes, a keto diet seems very fascinating to boost the weight loss results and control diabetes at the same time. However, the keto diet can have serious adverse effects on your health when you are using Ozempic. These are:
  • It is difficult to tolerate Ozempic with a Keto diet:

Ozempic causes bloating and fullness immediately after eating. A high-fat diet as in the keto diet has a similar effect on your stomach. Most people poorly tolerate Ozempic due to heaviness in the stomach and fullness after eating. Fullness and bloating sometimes persist throughout the day. Ozempic and keto diets are both associated with nausea and vomiting. This effect is multiplied when combining the two. A greater percentage of people on Ozempic have a change in their bowel habits. A keto diet can cause severe constipation. When using Ozempic, constipation can become very severe resulting in bleeding and intestinal obstruction. Your risk of hypoglycemia increases several folds: A keto diet is very deficient in carbohydrates. Among all the non-insulin medications, Ozempic has the greatest anti-diabetic effects. It lowers glycated hemoglobin significantly. When combining Ozempic and keto diets, the risk of hypoglycemia is very high. This is especially true if the person is taking insulin or sulfonylureas concomitantly.

There is a risk of pancreatitis:

A high-fat meal as in the keto diet can cause pancreatitis. Similarly, one of the most common side effects of Ozempic is pancreatitis. Combining Ozempic and keto diets can make a person prone to developing pancreatitis. pancreatitis is a life-threatening emergency. People with pancreatitis have severe abdominal pain radiating to the back, nausea, vomiting, and/or hypotension. Ozempic is contraindicated in patients with pancreatitis or a history of pancreatitis in the past. It is wise to avoid triggers that can result in pancreatitis such as a high-fat meal (keto diet).

Diabetic Ketoacidosis:

A keto diet is based on a fatty diet. When the body consumes a keto diet, ketone bodies are released. DKA or diabetic ketoacidosis is a serious complication of diabetes. It manifests as high blood glucose, ketones in urine or blood, and acidic blood. DKA is more common in type 1 diabetes patients. Ozempic is not for use in patients with T1DM. So, most patients on Ozempic have T2DM. T2DM patients who are on a keto diet [Ref] or novel diabetes medications, SGLT2 inhibitors (Empagliflozin and Dapagliflozin) are at risk of developing DKA. SGLT-2 inhibitors like Empagliflozin (Jardiance), Dapagliflozin (Farxiga), and Ertugliflozin (Steglatro) are commonly prescribed along with Ozempic.

In Conclusion:

Ozempic and keto diet combinations may be associated with serious health-related issues without any significant benefits. It is best to avoid Ozempic and keto diet combination as it may put you at risk of pancreatitis, DKA, and hypoglycemia. A keto diet may also increase the gastrointestinal side effects of Ozempic. It will worsen bloating, fullness, and constipation associated with Ozempic.

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Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

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