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Can Patients with Type 1 Diabetes Use Ozempic?

Ozempic for Type 1 Diabetes

type 1 diabetes mellitus insulin dependent diabetes mellitus ozempic for type 1

Can patients with Type 1 Diabetes use Ozempic? This question has two aspects:

  • Ozempic for type 1 diabetes patients to control blood glucose, or
  • Ozempic for type 1 diabetes patients to improve insulin resistance and lose weight

Not all patients with diabetes type 1 are thin and lean. Ozempic may result in weight loss in these patients and lower the risk of all the complications associated with obesity!

So, if we are talking about the role of Ozempic in type 1 diabetes patients for controlling hyperglycemia, the answer is “No“.

Ozempic Dosing for Weight Loss and Diabetes Mellitus

Ozempic for Type 1 Diabetes Patients to control blood glucose:

Patients with Type 1 diabetes mellitus are insulin-deficient. Ozempic (Semaglutide) lowers blood glucose by enhancing the release of insulin in a glucose-dependent mechanism.

Patients with type 1 diabetes are insulin deficient. There is absolute insulin deficiency. The Beta-cells are non-functional. Hence the beta-cells can not be stimulated to secrete insulin.

Mechanism of action of Semaglutide

The only treatment for patients with Type 1 diabetes mellitus is insulin. Recently, an SGLT-2 inhibitor (Dapagliflozin) has been approved by the EMA for the treatment of diabetes mellitus type 1 who are obese and not prone to ketosis.

However, physicians are still not comfortable prescribing dapagliflozin because of the risks of Euglycemic Ketoacidosis.

To conclude, Ozempic can not lower blood glucose in type 1 diabetes patients.

Insulin Dependent Diabetes Mellitus (IDDM) Type 1 and Type 2

Ozempic for Type 1 Diabetes patients for Weight loss and insulin resistance:

The weight loss mechanisms of Ozempic are slightly different than its glucose-lowering effects. Ozempic can be used theoretically for the treatment of obesity and insulin resistance in type 1 diabetes patients.

Insulin resistance is not very common in type 1 diabetes. However, in a subgroup of patients with type 1 diabetes who are obese and require higher doses of insulin may have concomitant insulin resistance.

Symptoms of High Insulin Levels & Insulin Resistance

Recently, two large trials evaluated the role of metformin in type 1 diabetes patients with insulin resistance. It was concluded that metformin lowers insulin requirements, reduces body weight, and LDL cholesterol at the risk of more gastrointestinal side effects [Ref]

Another review article evaluated the role of GLP-1 agonists in obese type 1 diabetic patients. It was observed that all GLP-1 lowered HbA1C, however, compared to a placebo medicine, the effect was non-significant.

In contrast to the blood-glucose-lowering effects, the weight loss effects of GLP-1 agonists were significant compared to placebo medicine [Ref].

Before and After Pictures & Reviews of People who are using Ozempic

A maximum weight loss of 6.4 kgs was observed over a period of 24 weeks. Liraglutide (Saxenda) was considered one of the best GLP-1 agonists that resulted in significant weight loss. However, in this review, studies on Ozempic use in obese T1 DM patients were not included.

This was probably because of a lack of data. Since Ozempic has proven to be superior to Liraglutide, it may be considered in obese patients with T1 DM who have suboptimal glucose control despite intensive insulin therapy.

Insulin Degludec (Tresiba) Dose, Class, Brands, Side effects, Conversion

In Conclusion:

Ozempic should not be used for hyperglycemia in patients with T1 DM, however, it can be considered a weight-loss medicine. More clinical trials are needed to evaluate the effect of Ozempic (or Wegovy) in patients with type 1 diabetes patients.

What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese, have diabetes, hypertension, high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.

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