Does Orilissa (Elagolix) Cause Weight Gain Or Weight Loss?

Orilissa is the medical name (Generic) of Elagolix. The drug has been approved for the treatment of pain associated with endometriosis that can not be controlled with other first-line of drugs and fibroids [Ref].

Orilissa (Elagolix) is not directly associated with weight loss or weight gain. However, people have reported changes in weight associated with Orilissa.

FDA-Approved indications of Orilissa (Elagolix):

Orilissa (elagolix) is approved for the following conditions:

Endometriosis-Associated Pain:

Moderate to severe pain associated with endometriosis in women.

Uterine Fibroids:

Moderate to severe pain associated with uterine fibroids in premenopausal women.

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How does Orilissa work?

ORILISSA is a medicine that blocks a hormone called GnRH in the pituitary gland.

By doing so, it reduces the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the body, which lowers the amounts of the female hormones estradiol and progesterone in the blood.

How to take Orilissa?

Orilissa is available in two different dosage strengths: 150 mg and 200 mg tablets. The dose is decided by your healthcare provider. However, it can be taken once or twice daily.

If you are taking Orilissa once daily, it’s typically recommended to take it at the same time each day. For example, you may choose to take it in the morning, or in the evening before bed.

If you are taking Orilissa twice daily, it’s typically recommended to space the doses about 12 hours apart.

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How long does it take for Orilissa to work?

Patients using Orilissa have noticed an improvement in symptoms within the first week. However, it is usually recommended for six months to 24 months depending on the underlying condition, tolerability, and effectiveness.

In clinical studies of Orilissa for endometriosis-associated pain, some patients reported a reduction in pain within the first week of treatment. However, it may take several weeks of treatment before a noticeable improvement in symptoms is seen. In these studies, patients took Orilissa for up to six months.

In clinical studies of Orilissa for uterine fibroids, patients typically took the medication for up to six months. In these studies, patients reported a reduction in pain within the first month of treatment, but it may take longer to see a significant reduction in the size of fibroids.

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Does Orilissa (elagolix) cause Weight Gain or Weight Loss?

Weight changes are a possible side effect of Orilissa (elagolix), but the medication does not typically cause significant weight gain or weight loss.

In clinical studies, weight gain was reported in some patients taking Orilissa, but the incidence was similar to the rate of weight gain seen in patients taking a placebo.

Similarly, weight loss was reported in some patients taking Orilissa, but again, the incidence was similar to that seen in patients taking a placebo.

It’s important to note that weight changes can be caused by a variety of factors, including changes in diet and exercise habits, hormonal fluctuations, and medication side effects.

What are the Pros and Cons of Orilissa?

Orilissa is associated with headaches, worsening migraines, weight gain or weight loss, and menopausal symptoms like hot flashes. It is more expensive than most other commonly used medicines.

However, it is very effective in reducing the pains associated with endometriosis and other symptoms of uterine fibroids.

Here is a table summarizing the Pros and Cons of Orilissa:

Pros	Cons
Reduces pain	Can cause hot flashes and headaches
Improves quality of life	Increases the risk of osteoporosis
Reduces the need for surgery	Interacts with other medications
Available in tablet form and is well-tolerated	Is expensive
May be effective in resistant cases	Not a cure for endometriosis or uterine fibroids

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Weight Gain or Weight Loss with Orilissa Vs other hormonal treatments:

Most hormonal therapies are associated with weight gain. Here is a table summarizing the effects of different hormonal treatments on body weight:

Drug	Weight Gain or Weight Loss
Orilissa	May cause weight gain or weight loss
Myfembree	May cause weight gain
Visanne	Not typically associated with weight gain or weight loss
Lupron	May cause weight gain
Oriahnn	May cause weight gain
Cetrotide	Not typically associated with weight gain or weight loss
Mirena	Not typically associated with weight gain or weight loss
Depo-Provera	May cause weight gain
Zoladex	May cause weight gain
Aygestin	May cause weight gain

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Is Orilissa associated with weight loss?

When searching on various social media platforms to see how people responded to Orilissa, it was observed that most individuals who reported experiencing weight loss also reported significant side effects such as headaches, nausea, fullness, loss of appetite (anorexia), and anxiety.

On the other hand, those who did not report significant side effects while taking Orilissa had only noticed minor changes in their weight.

It is important to note that the effects of Orilissa on weight can vary from person to person and that other factors such as diet and lifestyle may also contribute to changes in weight.

If you are on Orilissa and have gained or lost weight, kindly answer the poll below to see our user’s responses. “DEEPLY APPRECIATIVE“