Dr. Ahmed Semaglutide vs Dulaglutide is a comparison of the two novel GLP-1 analogs. Semaglutide is available in three formulations i.e. Rybelsus, Ozempic, and Wegovy. Dulaglutide is only available as a Trulicity Injection.
- Rybelsus is an oral tablet formulation available in tablets 3 mg, 7 mg, and 14 mg.
- Ozempic is available as 0.5 mg and 1.0 mg subcutaneous injections.
- Wegovy is available as a 2.4 mg once-weekly injection.
Trulicity is available as 0.75 mg and 1.5 mg subcutaneous once-weekly injections. These drugs exert their effects by acting as incretin mimetics.
Hence, they both cause the release of insulin and suppress glucagon in a glucose-dependent mechanism.
When glucose is elevated in the plasma, it causes the release of insulin and simultaneously suppresses glucagon levels.
These drugs also inhibit the motility of the stomach and delay gastric emptying.
This can cause nausea, vomiting, abdominal fullness, and bloating, and suppresses the appetite. Thus, they may also have a weight-losing effect.
However, the FDA has approved Semaglutide only for the management of obesity. Dulaglutide is only approved for the management of diabetes.
Similarities and Differences: Semaglutide Vs Dulaglutide:
Semaglutide | Dulaglutide | |
| Drug Class | GLP-1 analog | GLP-1 analog |
| Manufacturer’s Names | Novo Nordisk | Eli Lilly |
| Brand names |
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| Formulations available |
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| Indications | FDA-approved for Diabetes and Obesity | FDA-approved for Diabetes only |
| Cost Comparison |
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Semaglutide has three formulations. The FDA has approved two (Ozempic and Rybelsus) for the treatment of Diabetes Mellitus.
Rybelsus is administered as once-daily oral tablets while the other two formulations, Ozempic and Wegovy, like Trulicity, are administered once a week.
Wegovy is approved only for weight loss. On the other hand, Trulicity is only approved for the treatment of diabetes.
Semaglutide is more like the endogenously released GLP-1. It crosses the blood-brain barrier and has a greater effect on the hunger center of the brain compared to Dulaglutide (Trulicity).
In addition, Semaglutide is much more costly compared to Dulaglutide.
Pharmacokinetics Comparison of Semaglutide Vs Dulaglutide:
Semaglutide | Dulaglutide | |
| Peak Plasma concentrations | 1 – 3 days after a single dose | 24 to 72 hours |
| Half-life elimination | One week (It stays in the body for about 5 weeks) | Five days |
| Excretion/ Metabolism | Excreted in Urine and feces | It is metabolized into amino acids in the body |
| Administration | The oral tablet is administered once daily after meals. The injections are administered once weekly as a subcutaneous injection | It is administered once weekly subcutaneously into the anterior abdomen. |
The onset and duration of action of both these drugs are similar. Trulicity administration requires a little training before it can be injected by the person at home.
Ozempic and Wegovy can both be administered easily, just like insulin pens, where the dose is dialed and injected.
Semaglutide Vs Dulaglutide for Diabetes and Weight Loss:
Semaglutide | Dulaglutide | |
| Efficacy in Diabetes |
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| Weight loss effects |
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| Side effects |
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The efficacy of oral Semaglutide, Rybelsus, in lowering A1C and for weight loss is similar to Trulicity. However, the injectable formulations, Ozempic and Wegovy, are much more effective compared to Trulicity injections.
In fact, Wegovy has been approved as a weight loss medicine for individuals with or without diabetes.
In Summary:
Semaglutide (Rybelsus, Ozempic, and Wegovy) has a superior weight-losing effect compared to Trulicity (Dulaglutide).
Semaglutide is also more efficacious than Dulaglutide in terms of glycemic control.
Both Semaglutide and Dulaglutide are available as a once-weekly injection formulation, however, only Semaglutide is available as once-daily oral tablets.
Dulaglutide (Trulicity) is much cheaper than Semaglutide injections (Ozempic).
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