in ,

Dupixent Pen Vs Syringe: What’s the Difference

Dupixent Pen Vs Syringe

Dupixent Pen Vs Syringe: Which is easy to inject, less painful, and less costly? Here is a comparison of Dupixent prefilled pen devices vs Dupixent prefilled syringes.

Dupixent (Dupilumab): a breakthrough in biologic medicine …

Dupixent is a biological medicine that targets Interleukin 4 Receptor Alpha (IL-4Rα). It inhibits the processes that are executed by IL-4 and IL-13 since both these interleukins bind to IL4Rα.

It is used to treat the following conditions:

  • Atopic Dermatitis (Eczema)
  • Allergic or eosinophilic asthma
  • Chronic Rhinosinusitis with nasal polyps, and
  • Eosinophilic esophagitis.

It has been associated with paradoxical facial redness and eye problems, the cause of which is not very clear.

Dupixent is available as a pre-filled pen device as well as a pre-filled syringe. Whether you choose a pen-filled Dupixent device or a syringe, it’s up to you.

However, there are some minor differences between the two.


Dupixent Pen Vs Syringe:

Dupixent prefilled syringes can be used by children and adults while the prefilled pen is not recommended for use in younger children aged 12 years or younger.

A Dupixent syringe is available in doses of 100 mg, 200 mg, and 300 mg injections while a Dupixent pen is available in doses of 200 mg and 300 mg only.

Dupixent prefilled pen is kept at 90 degrees when injecting it. A Dupixent syringe is administered at 45 degrees.


Dupixent prefilled pen

Dupixent prefilled syringe

Age limitNot indicated in children younger than 12 years of ageIt can be administered to children who are 6 years of age or older
Dosage strengthsAvailable as 200 mg and 300 mg prefilled penAvailable as 100 mg, 200 mg, and 300 mg syringes
Angle of injection90 degrees45 degrees

The needle is visible in the syringe when injecting Dupixent while in the pre-filled pen device, the needle is covered by a needle cover.

People who have needle phobia should choose Dupixent pens rather than Dupixent syringes.

When injecting Dupliumab via Dupixent pen, you won’t see the needle going in. Once the pen is pushed against the skin, the needle cover goes up and the needle enters the skin.


Which is painful: Dupixent Pen Vs Syringe?

Different patients have different reviews. Most patients who are scared of needles don’t like prefilled syringes. For some patients, it was not the prick that hurt but the medicine.

If you are not scared of the needle and it’s the medicine that hurts when it is being injected, then the syringe is probably the best option.

Because you can control the speed of the injection when using a syringe, you can control the pain too. A slow injection may hurt less and you can inject it as slowly as over one minute or more.

Secondly, when using the Dupixent syringe, you can also control the angle at which to inject. For very skinny people, it may be best to inject at an angle of 45 degrees.

You can do that with the syringe but not when using the Dupixent prefilled pen.


What is the size (length, and gauge) of the needles of Dupixent Pen Vs Syringes?

The size of prefilled syringe needles are as follows:

  • Gauge: 27 gauge
  • Length: 12.7 mm or half-inch

The needle of prefilled Dupixent pen is hidden. One does not see it going into the skin and then coming back but can feel it.

Usually, pen devices have smaller needles but there may be very minimal difference between the two.


Which is costly: Dupixent Pen Vs Syringe?

Cost is a major issue with Dupixent unless you are getting it via your insurance coverage. Most people get injections or prefilled pens via Copay services or insurance.

Secondly, prices vary in different states. In some states, the prices of all the prefilled pen devices and prefilled syringes are the same.

Each prefilled pen and syringe costs:

Dupixent 100 mg/0.67 ml via syringe:

  • USD 3574 for two syringes
  • This is $ 1787 per injection

Dupixent 200 mg via syringe:

  • USD 1421 per 200 mg/1.14 ml syringe injection

Dupixent 300 mg via syringe:

  • USD 4967 for 2 injections of 300 mg/2mL
  • This is equivalent to $ 2483 USD per one 300 mg/2 mL injection.

Dupixent 200 mg via prefilled pen:

  • Two Dupixent 200 mg/ 1.14mL prefilled pens cost USD 3384
  • Each pen costs USD 1692.

Dupixent 300 mg via prefilled pen

  • Two 300 mg/2mL prefilled Dupixent pens cost USD 4910.
  • One prefilled 300 mg/2mL Dupixent pen costs USD 2455

What do you think?

Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

Here is a link to My Facebook Page. You can also contact me by email at or at My Twitter Account
You can also contact me via WhatsApp 🙏

Leave a Reply

Dupixent syringe and prefilled pen device

Dupixent How to Inject Using the Pen or the Syringe?

Dupixent atopic dermatitis dosing and dose in asthma, eosinophilic esophagitis, and nasal polyps

Dupixent Atopic Dermatitis Dosing and Dose in Allergic Asthma