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Dupixent Atopic Dermatitis Dosing and Dose in Allergic Asthma

Dupixent Atopic Dermatitis Dosing

Dupixent atopic dermatitis dosing and dose in asthma, eosinophilic esophagitis, and nasal polyps
Dupixent atopic dermatitis dosing and dose in asthma, eosinophilic esophagitis, and nasal polyps

Dupixent atopic dermatitis dosing and Dose in Allergic Asthma, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis are discussed here. Tables are made to make interpretations easier.

Dupixent atopic dermatitis dosing and dose in other conditions including allergic asthma vary a little bit.

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For the treatment of atopic dermatitis, allergic asthma, nasal polyps, and eosinophilic esophagitis, the manufacturer recommends following these schedules [Ref]:

Dupixent Dose in atopic dermatitis:

The dose of Dupixent is a little different than that of patients with allergic asthma. However, when comorbid asthma or another condition exists, the manufacturer recommends following the highest recommended dose.

For example, a patient with asthma and atopic dermatitis or nasal polyps is being prescribed Dupixent. Now, among the three comorbid conditions, atopic dermatitis requires the highest dose followed by asthma and nasal polyps.

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here, we should follow the dose recommended for patients with atopic dermatitis.

Dupixent atopic dermatitis dosing in Adults:

Dupixent Atopic dermatitis dosing in adults

Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every other week

Dupixent Atopic Dermatitis Dosing in Children who are 6 months to 5 years of age:

No loading dose is recommended. The initial starting dose and the subsequent dosing are the same.

Dupixent Atopic dermatitis dosing in Children (6 months to 5 years)

Body weight 5 kgs – 15 kgs One 200 mg injection is administered subcutaneously every four weeks (every month)
Body weight of more than 60 kg One 300 mg injection is administered subcutaneously every four weeks (every month)

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Dupixent atopic dermatitis dosing in children and Adolescents who are 6 years of age to 17 years of age:

Dupixent dosing in adolescents is based on the patient’s body weight:

Dupixent Atopic dermatitis dosing in Children (6 -17 years of age)

Body weight 15 kgs to less than 30 kgs Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every four weeks (every month)
Body weight of more than 30 kgs and less than 60 kg Loading Dose 400 mg subcutaneous

Two injections each of 200 mg strength are administered at two different sites

Maintenance dose 200 mg injection administered subcutaneously every other week
Body weight of more than 60 kg Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every other week

A simplified table is given in the picture below:

dupixent atopic dermatitis dosing in children

Dupixent atopic dermatitis dosing in children


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Dupixent Allergic Asthma Dosing:

The dose used to treat allergic asthma is slightly lower than that of patients with atopic dermatitis. Dupixent is recommended for the treatment of allergic asthma in children who are at least 6 years of age.

In the presence of comorbid conditions such as topics dermatitis, the dose that will treat both the conditions should be used. So, with concomitant atopic dermatitis and asthma, the dose used should be that used to treat atopic dermatitis.

Dupixent Allergic Asthma dosing in children 6 years to 11 years of age

Body weight 15 kgs – 30 kgs One 100 mg Dupixent injection is administered subcutaneously every other week, OR

300 mg injection administered every month (every four weeks)

Body weight of more than 30 kg One 300 mg injection is administered subcutaneously every four weeks (every month)

In children 6 to 11 years of age with Asthma and comorbid moderate to severe atopic dermatitis, the following dosing schedule should be followed:

Dupixent Dosing in Asthma + Atopic dermatitis dosing in Children

Body weight 15 kgs to less than 30 kgs Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every four weeks (every month)
Body weight of more than 30 kgs and less than 60 kg Loading Dose 400 mg subcutaneous

Two injections each of 200 mg strength are administered at two different sites

Maintenance dose 200 mg injection administered subcutaneously every other week
Body weight of more than 60 kg Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every other week

The table above is the same as that used to treat patients with atopic dermatitis:

dupixent dose in asthma alone

Dupixent dose in asthma and co-morbid atopic dermatitis

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Dupixent Allergic Asthma Dosing in adults and children who are 12 years of age or older:

Dupixent Atopic dermatitis dosing in Adults and Children 12 years of age or older
Children and Adults with Asthma alone Loading Dose 400 mg subcutaneous

Two injections each of 200 mg strength are administered at two different sites

Maintenance dose 200 mg injection administered subcutaneously every two weeks (twice monthly)
OR
Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every two weeks (twice monthly)
Dose in patients with:

1.      Oral corticosteroid-dependent asthma, or

2.      With comorbid moderate to severe atopic dermatitis, or

3.      Adults with comorbid rhinosinusitis with nasal polyposis

Loading Dose 600 mg subcutaneous

Two injections each of 300 mg strength are administered at two different sites

Maintenance dose 300 mg injection administered subcutaneously every other week

A simplified form of the above table is given here:

Children (>12 years) and Adults with Asthma alone

Loading Dose 400 mg (2 x 200 injections)
Maintenance dose 200 mg every two weeks

OR

Loading Dose 600 mg (2 x 300 injections)
Maintenance dose 300 every two weeks

Dose in patients with:

1.      Oral corticosteroid-dependent asthma, or

2.      With comorbid moderate to severe atopic dermatitis, or

3.      Adults with comorbid rhinosinusitis with nasal polyposis

Loading Dose 600 mg (2 x 300 injections)
Maintenance dose 300 mg injection every other week
Dupixent atopic dermatitis dosing and dose in asthma, eosinophilic esophagitis, and nasal polyps
Dupixent Dosing in adults with asthma alone or with comorbid medical conditions

Dupixent dose in adults with chronic rhinosinusitis with nasal polyposis:

The recommended dose in adults with chronic rhinosinusitis with nasal polyposis is 300 mg every other week


Dupixent dose in children 12 years of age or older and adults with eosinophilic esophagitis:

The recommended dose in adults and children who are 12 years of age or older and weigh at least 40 kgs is 300 mg subcutaneously every week

What do you think?

Written by Diabetes Doctor

I am an Internist practicing medicine for the last fifteen years. Over the years, I have learned that medicine is not about prescribing pills. True medical practice is helping people.
I do prescribe pills as well but the best results I get are when I motivate people to overcome their problems with little changes in their lifestyles.
Since most of my patients are obese, have diabetes, hypertension, high cholesterol levels, I am writing at dibesity.com when free.
Dibesity, I know the correct word is diabesity. Ignore this! Be with us.

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