Dr. Ahmed
Dupixent atopic dermatitis dosing and Dose in Allergic Asthma, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis are discussed here. Tables are made to make interpretations easier.
Dupixent atopic dermatitis dosing and dose in other conditions including allergic asthma vary a little bit.
For the treatment of atopic dermatitis, allergic asthma, nasal polyps, and eosinophilic esophagitis, the manufacturer recommends following these schedules [Ref]:
Dupixent Dose in atopic dermatitis:
The dose of Dupixent is a little different than that of patients with allergic asthma. However, when comorbid asthma or another condition exists, the manufacturer recommends following the highest recommended dose.
For example, a patient with asthma and atopic dermatitis or nasal polyps is being prescribed Dupixent.
Now, among the three comorbid conditions, atopic dermatitis requires the highest dose followed by asthma and nasal polyps.
here, we should follow the dose recommended for patients with atopic dermatitis.
Dupixent atopic dermatitis dosing in Adults:
Dupixent Atopic dermatitis dosing in adults | |
| Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites |
| Maintenance dose | 300 mg injection administered subcutaneously every other week |
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Dupixent Atopic Dermatitis Dosing in Children who are 6 months to 5 years of age:
No loading dose is recommended. The initial starting dose and the subsequent dosing are the same.
Dupixent Atopic dermatitis dosing in Children (6 months to 5 years) | |
| Body weight 5 kgs – 15 kgs | One 200 mg injection is administered subcutaneously every four weeks (every month) |
| Body weight of more than 60 kg | One 300 mg injection is administered subcutaneously every four weeks (every month) |
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Dupixent atopic dermatitis dosing in children and Adolescents who are 6 years of age to 17 years of age:
Dupixent dosing in adolescents is based on the patient’s body weight:
Dupixent Atopic dermatitis dosing in Children (6 -17 years of age) | ||
| Body weight 15 kgs to less than 30 kgs | Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites |
| Maintenance dose | 300 mg injection administered subcutaneously every four weeks (every month) | |
| Body weight of more than 30 kgs and less than 60 kg | Loading Dose | 400 mg subcutaneous Two injections each of 200 mg strength are administered at two different sites |
| Maintenance dose | 200 mg injection administered subcutaneously every other week | |
| Body weight of more than 60 kg | Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites |
| Maintenance dose | 300 mg injection administered subcutaneously every other week | |
A simplified table is given in the picture below:
Dupixent atopic dermatitis dosing in children
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Dupixent Allergic Asthma Dosing:
The dose used to treat allergic asthma is slightly lower than that of patients with atopic dermatitis. Dupixent is recommended for the treatment of allergic asthma in children who are at least 6 years of age.
In the presence of comorbid conditions such as topics dermatitis, the dose that will treat both conditions should be used.
So, with concomitant atopic dermatitis and asthma, the dose used should be that used to treat atopic dermatitis.
Dupixent Allergic Asthma dosing in children 6 years to 11 years of age | |
| Body weight 15 kgs – 30 kgs | One 100 mg Dupixent injection is administered subcutaneously every other week, OR 300 mg injection administered every month (every four weeks) |
| Body weight of more than 30 kg | One 300 mg injection is administered subcutaneously every four weeks (every month) |
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In children 6 to 11 years of age with Asthma and comorbid moderate to severe atopic dermatitis, the following dosing schedule should be followed:
Dupixent Dosing in Asthma + Atopic dermatitis dosing in Children | ||
| Body weight 15 kgs to less than 30 kgs | Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites |
| Maintenance dose | 300 mg injection administered subcutaneously every four weeks (every month) | |
| Body weight of more than 30 kgs and less than 60 kg | Loading Dose | 400 mg subcutaneous Two injections each of 200 mg strength are administered at two different sites |
| Maintenance dose | 200 mg injection administered subcutaneously every other week | |
| Body weight of more than 60 kg | Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites |
| Maintenance dose | 300 mg injection administered subcutaneously every other week | |
The table above is the same as that used to treat patients with atopic dermatitis:
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Dupixent Allergic Asthma Dosing in adults and children who are 12 years of age or older:
| Dupixent Atopic dermatitis dosing in Adults and Children 12 years of age or older | ||
| Children and Adults with Asthma alone | Loading Dose | 400 mg subcutaneous Two injections each of 200 mg strength are administered at two different sites |
| Maintenance dose | 200 mg injection administered subcutaneously every two weeks (twice monthly) | |
| OR | ||
| Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites | |
| Maintenance dose | 300 mg injection administered subcutaneously every two weeks (twice monthly) | |
| Dose in patients with: 1. Oral corticosteroid-dependent asthma, or 2. With comorbid moderate to severe atopic dermatitis, or 3. Adults with comorbid rhinosinusitis with nasal polyposis | Loading Dose | 600 mg subcutaneous Two injections each of 300 mg strength are administered at two different sites |
| Maintenance dose | 300 mg injection administered subcutaneously every other week | |
A simplified form of the above table is given here:
Children (>12 years) and Adults with Asthma alone | |
| Loading Dose | 400 mg (2 x 200 injections) |
| Maintenance dose | 200 mg every two weeks |
OR | |
| Loading Dose | 600 mg (2 x 300 injections) |
| Maintenance dose | 300 every two weeks |
Dose in patients with: 1. Oral corticosteroid-dependent asthma, or 2. With comorbid moderate to severe atopic dermatitis, or 3. Adults with comorbid rhinosinusitis with nasal polyposis | |
| Loading Dose | 600 mg (2 x 300 injections) |
| Maintenance dose | 300 mg injection every other week |
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Dupixent dose in adults with chronic rhinosinusitis with nasal polyposis:
The recommended dose in adults with chronic rhinosinusitis with nasal polyposis is 300 mg every other week
Dupixent dose in children 12 years of age or older and adults with eosinophilic esophagitis:
The recommended dose in adults and children who are 12 years of age or older and weigh at least 40 kgs is 300 mg subcutaneously every week.
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