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Combining Wegovy, Ozempic, and Tirzepatide with B6

Tirzepatide with B6

Different weight loss clinics that enroll patients for weekly follow-ups of the latest once-a-week weight loss shots combine these injections with Vitamin B6 and provide them with a customized meal plan and exercise guidance.

Exercise and weight loss meal plans are understandable. However, why do these clinics administer Vitamin B6 (Pyridoxine) along with Wegovy, Ozempic, or Tirzepatide to their obese patients?

Does Vitamin B6 (Pyridoxine) augment the weight loss effects of these injections?

Let’s explore the role of Wegovy, Ozempic, and Tirzepatide with Vitamin B6 in managing obesity.

Why is B6 Supplementation Essential?

Vitamin B6 is an important nutrient that helps our body work properly, especially our nerves, brain, skin, and blood.

If you don’t get enough Vitamin B6 (also called Pyridoxine), you might have nerve problems.

This can make your arms and legs feel weak, cause a burning or tingling sensation, make you lose your balance, and lead to mental health issues.

Not having enough Pyridoxine can also cause cracked lips, a swollen tongue, and anemia, which means you don’t have enough red blood cells.

These symptoms are common in people who are on a weight-loss diet or taking weight-loss medications.

Nerve problems are also common in overweight people who have diabetes or high blood sugar.

Pyridoxine deficiency can happen to those who don’t eat a balanced diet or are on extreme diets, often along with other nutrient deficiencies.


Health Benefits of Wegovy, Ozempic, and Tirzepatide with B6:

Vitamin B6 boosts your metabolism, helps remove bad cholesterol from your body, and improves nerve-related symptoms like tingling, numbness, fatigue, and weakness.

It also alleviates gastrointestinal symptoms like nausea and vomiting. In fact, it’s one of the primary medicines approved for treating nausea and vomiting in pregnant women.

Combining Wegovy, Ozempic, or Tirzepatide with B6 may enhance the weight loss effects of these drugs.

In a recent study, Pyridoxine significantly improved metabolic parameters in obese individuals.

In this study, 44 overweight and obese women, aged 18-50, were randomly divided into two groups:

  • Intervention Group: Received 80 mg of vitamin B6 (pyridoxine hydrochloride) for 8 weeks.
  • Control Group: Received a placebo (a harmless pill with no active ingredients) for 8 weeks.

The study found that the women who took vitamin B6 showed improvements in various health measures, while those in the control group did not.

Here are the main results:

  • Weight, BMI, fat mass, and waist size decreased.
  • Visceral Adiposity Index (VAI), fasting insulin levels, insulin resistance, total cholesterol, LDL cholesterol, triglycerides, and leptin levels all decreased.
  • Adiponectin levels (a protein that helps regulate glucose levels and fatty acid breakdown) increased.

Comparing the two groups after 8 weeks, there were significant differences in fat mass, VAI, fasting insulin, insulin resistance, and triglycerides, favoring the vitamin B6 group.

These results suggest that vitamin B6 supplements might help reduce BMI and improve body composition and other health markers linked to obesity.

The table below summarizes the important outcomes of the study and their significance:



Significance (p-value)

Body Mass Index (BMI)0.023
Fat Mass0.003
Waist Circumference0.005
Visceral Adiposity Index (VAI)0.001
Fasting Insulin< 0.001
Insulin Resistance (HOMA-IR)< 0.001
Total Cholesterol< 0.001
Low-density lipoprotein (LDL)< 0.001
Triglycerides (TG)< 0.001
Leptin< 0.001
Adiponectin< 0.001
Fat Mass (between groups)Significant< 0.05
VAI (between groups)Significant< 0.05
Fasting Insulin (between groups)Significant< 0.05
HOMA-IR (between groups)Significant< 0.05
Triglycerides (between groups)Significant< 0.05

A P-value of less than 0.05 is considered significant

These findings indicate that vitamin B6 supplementation could be beneficial for reducing BMI and improving health measures related to obesity.


Does Tirzepatide with B6 help you lose more weight?

There aren’t any studies yet on how combining Vitamin B6 with Tirzepatide affects weight loss.

However, some theories suggest that researchers should look into this combination.

When your body lacks vitamins, you tend to crave foods rich in vitamins. While these foods can help restore your vitamin levels, they can also add extra calories, leading to weight gain.

Adding Vitamin B6 to Tirzepatide might help with nerve-related symptoms and reduce the nausea and vomiting that Tirzepatide can cause.

So, taking Vitamin B6 with Tirzepatide could make it easier to tolerate Tirzepatide, allowing you to take higher doses, especially if you have severe gastrointestinal symptoms.

Therefore, taking vitamin B6 supplements while on a weight-loss diet or medication might make sense.


Does Wegovy plus B6 help you lose more weight?

The same applies to Wegovy and Ozempic, which are also weekly injections like Tirzepatide.

These medications help with weight loss mainly by making you feel full, leading to anorexia, loss of appetite, nausea, bloating, and fullness for many users.

Nausea and abdominal discomfort are common side effects of these drugs.

Taking Vitamin B6 can help you better tolerate these medications by reducing nausea and vomiting.

Unlike most anti-nausea medications like dimenhydrinate (Dramamine), promethazine (Phenergan), and metoclopramide (Maxolon), which can cause weight gain, Vitamin B6 (pyridoxine) may actually help with weight loss while also easing nausea symptoms.


In conclusion:

Vitamin B6 is an essential nutrient needed for various body functions, including nerve healing, blood cell production, and metabolism.

It can contribute to slight weight loss and improve metabolic health by lowering bad cholesterol and reducing visceral fat.

Additionally, it helps alleviate nausea and vomiting often associated with weight loss medications.

Therefore, Vitamin B6 supplementation with weight loss medicines can help in two ways:

  • It helps you tolerate Wegovy, Ozempic, and Tirzepatide by relieving gastrointestinal side effects like nausea.
    It may relieve nerve pain symptoms and improve your metabolism, supporting weight loss.

Lastly, it’s important to maintain a healthy diet that includes Vitamin B6. If you’re taking Vitamin B6 supplements, try not to exceed 200 mg per day.

Higher doses of Vitamin B6 can paradoxically worsen neuropathic symptoms. While low doses can treat neuropathy, toxic doses can actually cause it.


What do you think?

Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

Here is a link to My Facebook Page. You can also contact me by email at or at My Twitter Account
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