Golimumab (Simponi): Uses, Dose, MOA, Side effects

Golimumab (Simponi)

Golimumab (Simponi) is an immunosuppressive medicine that is used in the treatment of inflammatory conditions such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.

Other TNF inhibitors include:

In this article, we will discuss the uses, mechanism of action, dosage, and side effects of Simponi.

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What is Simponi?

Golimumab (Simponi) belongs to a class of medications known as biologics. Simponi is the brand name for golimumab.

Adults with active psoriatic arthritis, active ankylosing spondylitis, or moderate to severe rheumatoid arthritis can receive treatment with golimumab.

It is injected beneath the skin to treat ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis symptoms such as joint swelling, discomfort, exhaustion, and morning stiffness. It can also be administered as an infusion.

Uses of Simponi

This medicine is used to lessen the pain and swelling associated with some forms of arthritis (such as rheumatoid, psoriatic, and ankylosing spondylitis).

Tumor necrosis factor, or TNF, is a protein produced by the immune system of the body that damages and swells joints. It is blocked by this medication.

The medicine aids in preventing additional joint damage by lowering joint swelling and maintaining joint function.

Depending on the type of arthritis being treated, this medication may be used either by itself or in conjunction with another medication called methotrexate.

Additionally, this drug is employed to treat a specific digestive issue (ulcerative colitis). It is used to aid in reducing the signs and symptoms of moderate to severe ulcerative colitis (such as cramps, diarrhea, and bloody stools).

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Mechanism of action of Simponi

Golimumab, a monoclonal antibody, is the active ingredient in Simponi. A monoclonal antibody is a type of protein that has been developed to recognize and attach to a specific structure found in the body (called an antigen).

Golimumab is intended to bind to and inhibit a molecule in the body known as tumor necrosis factor-alpha (TNF-a).

This substance plays a role in inflammation and is detected in high concentrations in people with the conditions Simponi is used to treat.

Golimumab decreases inflammation and other symptoms of these disorders by inhibiting TNF-a [ref].

Direction to use Simponi

Golimumab is available as an automated injector or a syringe with a prefilled needle (pen). Take this drug precisely as directed. Administer this medication once a month by injection under the skin of the thigh, abdomen, or upper arm, as advised by your doctor.

Remove this medication from the refrigerator and set it aside for at least 30 minutes before injecting. Do not reheat this medication in any other manner, such as by placing it in hot water or heating it in the microwave.

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Side effects of Simponi [ref]

Simponi can have side effects, like any other medication. Keep in mind that your doctor has recommended this medication because they believe it will benefit you more than it will harm you. Many persons who take this medicine report no significant negative effects.

Serious infection

Infection is the most frequent major side effect. Moreover, golimumab diminishes the body’s ability to fight infection. If you experience any symptoms, such as fever, coughing, or red or sore skin, or if you plan to undergo surgery, be sure to call your doctor.

Golimumab may need to be stopped while you’re receiving infection-related treatment. If you are contemplating surgery, you might also need to pause.

Reaction at the injection site

Some patients may have pain, redness, or swelling at the site of the injection. After a month of treatment, these responses should subside. Changing the injection site regularly will lessen the likelihood of this happening.

Allergic reaction

In rare situations, people develop an allergic reaction. You can feel out of breath or have a rash or swelling instead. Get medical help right away if you have any of these or any other serious effects during or soon after receiving a dose of golimumab.

Immune system issues

Golimumab may make you more susceptible to infections and cold-like symptoms since it suppresses your immune system.  Immediately report any of the following symptoms to your doctor or rheumatology nurse:

  • A persistent cough
  • Unexplained weight loss

Heart problems

People who use TNF blockers, such as Simponi, can develop heart failure or already have it get worse.

If you experience any heart disease symptoms, such as shortness of breath when lying down or exerting yourself, swelling or edema in your legs, ankles, or feet, or chest pain or heaviness, be sure to let your doctor know. Your heart problems can worsen if you take this class of medications.

Blood issues

Simponi can cause low blood counts. If this happens, your body might not produce enough blood cells to combat infections or stop bleeding.

Your doctor will examine your blood counts, during treatment or before it. If you experience symptoms like fever, bruises, easy bleeding, or pallor, let your doctor know.

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Dosage information of Simponi

Dosage for Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis

Simponi 50 mg once a month via subcutaneous injection.

Use Simponi in conjunction with methotrexate in patients with rheumatoid arthritis (RA), and alongside or without methotrexate in patients with ankylosing spondylitis (AS) or psoriatic arthritis (PsA).

Dosage for Ulcerative Colitis

Dosage Timing
200 mg0 weeks
100 mg2-week
100 mgEvery 4-week


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Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

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