Dr. Ahmed Motegrity Weight Loss or Prucalopride-associated weight loss has not been adequately studied in clinical trials. It has been associated with the perception of weight loss, though.
How does Motegrity work?
Motegrity or Prucalopride is a 5-HT4 receptor activator. 5-HT4 is a subtype of serotonin receptors that are present in abundance in the intestinal tract.
Activation of these specific types of serotonin receptors enhances gut motility. Thus, this novel class of medicines is used primarily in the treatment of chronic constipation.
How does Motegrity Affect Changes in Body Weight?
As Prucalopride acts primarily in the intestinal serotonin receptors, most of its side effects are related to the gastrointestinal tract.
Most gastrointestinal GI side effects are associated with changes in body weight.
Individuals who have been on Motegrity (Prucalopride) have reported mixed symptoms of weight loss, weight gain, and no change in weight.
The effect of Motegrity on body weight has not been evaluated in clinical trials. In one study, for patients who had diabetes or connective tissue associated with gastroparesis, treatment with Prucalopride resulted in an increased perception of weight loss [Ref].
Although weight loss was not clinically documented, patients reported that they lost weight with Prucalopride.
Motegrity (Prucalopride) associated weight loss could be a result of any of the following effects of Prucalopride:
Motegrity impairs absorption:
- Serotonin receptor activation may increase intestinal motility and might affect the absorption of food. Loss of calories from the GI tract may be associated with weight loss
Motegrity suppresses appetite:
- One of the side effects of Motegrity is loss of appetite. A reduced appetite is directly associated with reduced food intake. Less food intake will cause a gradual weight loss.
People on social media have reported up to 50 lbs of weight loss with Motegrity. Most of the weight loss reported with Motegrity occurred during the first three months.
In addition, people who reported weight loss associated it with an improvement in wellbeing, bloating, and constipation.
However, the Motegrity weight loss effect lasted only a short while, after which patients regained their body weight.
In conclusion:
Weight loss associated with Motegrity is probably a result of better well-being, better eating habits, and exercise rather than a direct effect of Motegrity.
However, the weight loss effects of Prucalopride need to be investigated.
- 97% Pure Berberine Powder – High-purity, plant-derived extract with a rich yellow color. Carefully processed and lab-tes…
- Naturally Bitter Taste – Berberine has a strong, naturally bitter flavor. Best enjoyed when mixed with smoothies, tea, c…
- 100g in Resealable Foil Pouch – Packaged in a premium aluminum pouch to protect from moisture and light, keeping the pow…
- 5 Delicious Flavors: Freeze-Dried Mango, Freeze-Dried Blueberry, Freeze-Dried Orange, Freeze-Dried Dragon Fruit & Freeze…
- Pure and Natural Ingredients: Our fruit powders are made without synthetic pesticides, GMOs, or harmful chemicals. Each …
- Health Benefits: Our carefully selected fruits are packed with antioxidants, vitamins, fiber, and digestive enzymes to s…
- 🌿 4 Tangy Citrus Flavors in One Pack: Enjoy a delicious variety of Orange, Lime, Lemon, and Kiwi powder – 5 sachets of e…
- 💧Easy to Mix & Refreshing: Just add to water, smoothies, sparkling drinks, or tea for a vibrant citrus kick. Dissolves i…
- 🛡️Rich in Vitamin C & Antioxidants: Made from real fruit powders, this mix offers a natural source of vitamin C to suppo…
- VARIETY PACK – Includes 5 delicious organic berry powder flavors: Freeze-Dried Goji Berry, Freeze-Dried Strawberry, Free…
- PURE INGREDIENTS – Made with 100% natural, freeze-dried berries and absolutely no added sugar, artificial ingredients, o…
- CONVENIENT PACKAGING – Contains 20 pre-portioned 5g packets (100g total), eliminating the need for measuring and ensurin…
