How to Get Rid of Air Bubbles in Your Ozempic Pen?

Clearing Air Bubbles in Ozempic Pen

Now that most of you are using Ozempic and Mounjaro pens for controlling weight and managing your diabetes, some of you might be facing difficulties in handling the pen devices.

To get the most out of your Ozempic and Mounjaro journey, it is important to inject the correct dose, at the recommended time interval, step up the dose as per the FDA and manufacturer’s recommendations, and most importantly, inject Ozempic and not some counterfeit Ozempic injection.

Ozempic comes in a pre-filled injection device. The packaging contains one Ozempic pen and six ultrafine needles.

It is recommended to keep it under optimal temperature, preferably in a refrigerator but avoid freezing it.

Before injecting it, you need to gently swirl the pen in your hands to mix the solution. Prime the pen by first pressing the injector and then set the dose.

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During this process, you may sometimes notice bubbles in your Ozempic pen. Bubbles are more likely to appear if you shake the pen or you drop it.

Such bubbles in your Ozempic pen can disturb the amount of dose, and you won’t be getting the full quantity of medication that you require.


Why You Should Remove Air Bubbles From Your Ozempic Pen?

Even though the tiny bubbles seem insignificant, they can wreak havoc on your medicine dose in two ways:

  • Dosage disruption:

The gas bubbles act like intruders in the pen’s reservoir. They disturb the dose amount by occupying a specific volume of the Ozempic liquid.

Ozempic needs to be delivered in a precise dose to be effective, so even a single bubble can disrupt the balance.

It is like baking a cake, but the flour is filled with air pockets, so the final product would be a disaster. The same principle applies to your Ozempic dose.

  • Injection discomfort:

While it might not affect everyone, the air bubbles can often deliver an unpleasant injection experience.

Their presence could induce a stinging or burning sensation at the injection site. And as we know, nobody wants to put air in their body, be it a few bubbles instead of their medicine, right?

By sparing some time and removing any air, you get the right amount of medicine for your health. It also maximizes your comfort during the injection process.


How Do You Remove Air Bubbles From Your Ozempic Pen?

Now that you understand ‘why’ you need to remove the bubbles, let’s get down to the ‘how.’ Here is a step-by-step guide to make sure your pen is free of air.


  • Clean hands are key:

A mix of soap and water is enough to clean your hands properly. Dry them with a clean towel or tissue paper to avoid any cross-contamination.

  • Gather your supplies:

Make sure you have everything you need within reach:

  • Your Ozempic pen
  • An alcohol swab for cleaning
  • A new, sterile pen needle

Checking the medication:

The pen has a window to help you peek at the medicine. So, before you attach a new needle, make sure the area is clean and not cloudy; in other cases, don’t use the pen and consult your healthcare physician.

Attaching the needle:

  • Screw on the new needle:

The pen has a threaded tip, and that’s where the new sterile pen needle should be firmly attached. To prevent any leaks, the needle must be screwed tightly.

  • Clean the injection site:

Another way to avoid contamination is by cleaning the area with an alcohol swab. Let the injection site air dry before proceeding.

Priming the pen (expelling air):

  • Turn the dose knob:

There is a dose selector knob on your pen. Rotate it to face the flow check symbol, which is represented by a stream or droplet icon. Look at the pen’s manual if you don’t find it.

  • Upright and ready:

Hold your pen in an upright position where your needle points upwards. Thanks to physics, the air bubbles will rise to the top.

  • Press the button:

Then you can press the injection button gently. It will make a clicking sound. Hold the button in that position until you see a drop of medication on the needle tip. This shows that the gas bubbles have been expelled.

  • Repeat:

If no drop appears at the tip, repeat the steps above. If you still do not see it after multiple attempts, then discard the pen and use a new one with a fresh needle.


Additional tips

Enhancing Your Ozempic Experience

The essential steps have been covered above, and here are a few bonus tips to make sure your Ozempic pen is bubble-free

  • The tapping technique:

Once the needle is attached, gently tap the pen barrel with your index finger. This will force any remaining air bubbles to ride towards the top of the liquid medicine.

  • Needle disposal for safety:

After you have primed the pen and the drop has appeared, you need to discard the needle.

As the needle is no longer sterile after use, detach it from the pen. Do not just throw it in the bin; wrap it in a piece of paper first.


Safety information

  • Fresh needle, every time:

Reusing Ozempic needles is safe. However, it is best to use a new needle each time.

The manufacturer provides extra needles with your pen. If you lose the needles, you can buy ultrafine Novopen needles which are used to inject insulin.

  • Doctor’s orders are key:

We have listed every piece of info that will help you remove bubbles, but a doctor’s precise instructions for using the pen are more useful.

There is a leaflet inside the Ozempic box, and you can refer to it or consult a healthcare professional with further questions.



Expelling any bubbles present in the pen is a critical step that makes sure that you receive an accurate medication delivery each time.

As you follow the guidelines given above, you can confidently manage the injections and their dosage and experience the full benefits of the treatment.

Even though we are confident that the information above is enough to help you remove bubbles, we still recommend consulting a doctor.

If you have any specific questions about using the Ozempic pen, then contact your physician without hesitation.


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Written by Dr. Ahmed

I am Dr. Ahmed (MBBS; FCPS Medicine), an Internist and a practicing physician. I am in the medical field for over fifteen years working in one of the busiest hospitals and writing medical posts for over 5 years.

I love my family, my profession, my blog, nature, hiking, and simple life. Read more about me, my family, and my qualifications

Here is a link to My Facebook Page. You can also contact me by email at or at My Twitter Account
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